Massive congenital intracranial immature teratoma: An autopsy report

Thakran, A; Rao, Seema; Sreenivas, M.; Khurana, Nita

doi:10.4103/0377-4929.97914

Cited by 4 publications

(3 citation statements)

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“…Teratomas are classified pathologically into mature, immature, and malignant subtypes. [17][18][19] Mature teratomas (MTs) are composed of well-differentiated elements, whereas immature teratomas contain components resembling fetal tissues. 20 Intracranial MTs are tumors with a very low incidence (0.2%) and clear male predominance (5:1).…”

Section: Discussionmentioning

confidence: 99%

“…18 These lesions are believed to be originated from an abnormal distribution of germ cells, during the third to fourth week of gestation. 17,18,20 Teratomas have two peaks in their age distribution: 10% occur before 5 years of age, whereas 48% occur between 5 and 14 years of age. Some consider that the first peak of incidence is due to sequestration of blastocyst cells, before differentiation has occurred.…”

Section: Discussionmentioning

confidence: 99%

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Intracranial Mature Teratoma: A Case Report

Filho¹,

Carli

Araújo³

et al. 2016

Arq Bras Neurocir

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Teratomas are the most common type of Germ Cell Tumors (GCTs). GCTs are classified as extragonadal, if there is no evidence of a primary tumor in neither the testicles, nor in the ovaries. Intracranial Mature Teratomas are tumors with a very low incidence, and clear male predominance. We present the case of a 21 year-old female patient, with a history of two seizures 15 days prior to admission, without any abnormalities upon physical examination. The Magnetic Resonance Imaging (MRI) performed at the admission evidenced an expansive, heterogeneous lesion in the frontal lobe, hypointense on T1-weighted images, hyperintense on T2-weighted images, and restriction on the diffusion imaging and ADC-mapping. The patient underwent microsurgical resection, and it was possible to achieve a near-total resection. During surgery, a welldefined capsule was identified, which was removed after adequate debulking. Tissues resembling hair were taken from inside the lesion. The patient recovered well, without any neurological deficits, and no further intervention was necessary. The authors aim to describe this rare pathology and their option for a surgical approach. Palavras-chave► neoplasia cerebral ► tumor células germinativas ► neurocirurgia ResumoOs teratomas são o tipo mais comum de Tumores de Células Germinativas (TCG). TGC são classificados como extragonadais, quando não há evidências de um tumor primário em nos testículos, ou nos ovários. Os Teratomas Maduros Intracranianas são tumores com uma incidência muito baixa, e com uma predileção pelo sexo masculino. Nós apresentamos o caso de uma paciente, feminina, 21 anos de idade, com história de dois episódios de convulsões tônico-clônicas generalizadas, 15 dias antes da admissão, sem nenhum déficit focal ao exame físico. A Ressonância Magnética realizada na chegada mostrou uma lesão sólida, expansiva, grande e heterogênea, hipointensa em T1, e hiperintensa em T2, com restrição a difusão e ADC-mapping. Foi realizado uma cirurgia, e foi possível obter uma ressecção quase total. Havia uma cápsula bem definida, a qual foi removida após adequada redução do volume tumoral. Dentro da lesão foi encontrado tecido semelhante a cabelo. A paciente se recuperou bem, e foi dado alta sem novos déficits neurológicos, não foi realizado mais nenhuma intervenção, e ela está sendo acompanhada regularmente. Os autores visam descrever essa patologia rara e sua opção por uma abordagem cirúrgica.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Intracranial Mature Teratoma: A Case Report

Filho¹,

Carli

Araújo³

et al. 2016

Arq Bras Neurocir

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“…[ 3 , 4 ] Congenital tumors usually involve a relatively wide area of the brain. [ 5 , 6 ] The prognoses of primary intracranial immature teratomas in the fetus and newborn are generally poor, [ 4 , 7 – 11 ] while prognostic data in adults are currently lacking. Herein, we report a rare case of primary intracranial immature teratoma in a 27-year-old woman.…”

Section: Introductionmentioning

confidence: 99%

Intracranial immature teratoma invading the nasal cavity mimicking olfactory neuroblastoma

et al. 2018

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Rationale:Primary intracranial immature teratoma accounts for majority of congenital central nervous system germ-cell tumors, but it is extremely rare in patients older than 15 years.Patient concerns:A 27-year-old woman was referred to our hospital for headache, nasal congestion, and decreased olfactory sensation. Imaging showed a mass measuring approximately 5 cm × 4 cm in the right frontal lobe, which also filled the right nasal cavity. Histopathologically, the intracranial tumor tissues were composed of both mature tissues, including glands and squamous epithelial cells and immature neuroectodermal components. However, the tumor tissues in the nasal cavity were mainly immature neuroectodermal components that mimicked olfactory neuroblastoma. The cells stained positively for neuron-specific enolase, Alpha Thalassemia/Mental Retardation Syndrome X-Linked, and Oligodendrocyte transcription factor on immunostaining, proving a neuroectodermal differentiation.Diagnoses:According to these findings, the tumor was diagnosed as a primary intracranial immature teratoma that also involved the nasal cavity after excluding the metastatic tumors.Interventions:The patient underwent 2 surgeries. The first surgery was via the subfrontal approach, followed by a second endoscopic sinus surgery performed 22 days later.Outcomes:The patient had no recurrence within a 6-month follow-up after the last surgery.Lessons:When an intracranial immature teratoma involves the nasal cavity, the lesions in the nasal cavity may mimic other tumors including olfactory neuroblastoma. We suggest that thorough examination of tumor tissues and identification of variable components are critical for the appropriate diagnosis of intracranial immature teratoma, a rare tumor.

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