“…5 The predisposing factor(s) responsible for HT are not well defined, although etiology (thrombotic versus embolic), [5][6][7] collateral circulation, 8,9 reperfusion, 10 hypertension, 6,8,[11][12][13] size of the ischemic lesion, 5,14 -20 and the use of anticoagulants, thrombolytics, [21][22][23][24] or both have been implicated. No precise predictors of HT have been determined, but caution is suggested when thrombolysis is considered in patients with early x-ray CT signs of major stroke such as sulcal effacement, mass effect, edema, or possible hemorrhage 25,26 or National Institutes of Health Stroke Scale score greater than 22.…”