Massive bleeding from esophageal cancer

Ghosh, Bimal C.; Choudhry, Karamat U.; Beattie, Edward J.

doi:10.1016/s0022-5223(19)41828-x

Cited by 10 publications

(1 citation statement)

References 7 publications

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“…Spontaneous rupture of major vessels like the aorta is described as an extremely rare complication after radiation. [1][2][3][4][5][6] Tissue damaging side-effects of cytotoxic agents used for chemotherapy can also affect vessel walls. 7 Tissue damage by surgery and postoperative infections can predispose vessels to rupture.…”

Section: Introductionmentioning

confidence: 99%

Delayed aortic rupture after radiochemotherapy and esophagectomy for esophageal cancer

Rahden¹,

Stein²,

Reiter

et al. 2003

Diseases of the Esophagus

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Spontaneous rupture of major vessels is a known though rare complication in treatment of patients with esophageal cancer, but its pathophysiology is not very well understood. We herein report about the sudden death of a 42-year-old man due to spontaneous aortic rupture, 11 days after transthoracic esophagectomy. Because of a locally advanced squamous cell carcinoma of the distal esophagus, which was considered irresectable at the time of presentation, the patient had received one course of chemotherapy followed by synchronous chemoradiation (60 Gy, 5-fluorouracil and cisplatin) prior to surgery. We discuss the patho-anatomic findings of the postmortem examination concerning alterations of the aortic wall and the potential correlations with aggressive radiochemotherapy protocols.

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Section: Introductionmentioning

confidence: 99%

Delayed aortic rupture after radiochemotherapy and esophagectomy for esophageal cancer

Rahden¹,

Stein²,

Reiter

et al. 2003

Diseases of the Esophagus

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Acquired Esophageal Fistula

Geboes¹,

Valembois²

1974

Diseases of the Esophagus

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A 25-year review of adenocarcinoma of the appendix

Cerame¹

1988

Diseases of the Colon &Amp; Rectum

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A study was undertaken to compare the age, sex, preoperative diagnosis, and operative findings of patients who had adenocarcinoma of the appendix with patients who had adenocarcinoma of the colon. The study consisted of an analysis of 316 case reports and collective reviews of adenocarcinoma of the appendix that were reported in the literature between 1960 and 1985. The mean age of patients with this disease was 57.1 years and the male-to-female ratio for adenocarcinoma of the appendix was 1.4:1. Only rarely was a malignancy suspected, as 68 percent of the patients presented with signs and symptoms of inflammatory disease of the appendix. The tumor was perforated in 55 percent of patients, making it the most frequently perforating carcinoma of the entire gastrointestinal tract. One half of these perforations were localized as abscesses. The presence of perforation did not necessarily predispose a poor prognosis. Synchronous appendiceal and other colonic neoplasms occurred in 2.7 percent of patients. Pseudomyxoma peritonei occurred as a presenting feature in 5.6 percent of patients and was generally a poor prognostic indicator. Carcinomatosis peritonei was found at initial exploration in 10.3 percent of patients and these patients rarely survived one year.

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Massive bleeding from esophageal cancer

Cited by 10 publications

References 7 publications

Delayed aortic rupture after radiochemotherapy and esophagectomy for esophageal cancer

Delayed aortic rupture after radiochemotherapy and esophagectomy for esophageal cancer

Acquired Esophageal Fistula

A 25-year review of adenocarcinoma of the appendix

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