Massive bilateral mandibular metastasis from papillary thyroid carcinoma

Metastatic papillary thyroid carcinoma of the mandible: Case report and literature review

“…Distant metastasis from PTC is very rare because it usually remains intraglandular or metastasize to regional cervical lymph nodes through the lymphatic system although follicular thyroid carcinoma with hematogenous spread causes more frequent distant metastasis. [ 1 18 19 ] Metastasis to the jaw bone develops through blood vessels, that is the most common route. [ 14 ]…”

“…[ 2 16 ] Ramus and angle of the mandible due to rich blood circulation in the medullary cavity are most locations to metastasis[ 3 4 22 ] and in radiography has been shown with poorly defined osteolytic lesion with ragged border. [ 1 ]…”

“…Malignancy of the thyroid gland is the most common in the endocrine system and has been identified into different subtypes depending on the cells or growth pattern. [ 1 2 ] Papillary thyroid carcinoma (PTC), a well-differentiated tumor, is the most common histological subtype including 80%–90% of all thyroid cancer. [ 3 4 ]…”

“…[ 2 3 5 ] Mandibular metastasis is rare, and it counts about 1% of oral malignancies. [ 1 6 ] This tumor almost presents in the premolar-molar and angle-ramus region of the mandible. [ 3 7 ]…”