We study the effect of dimerization (due to, e.g., spin-Peierls instability) on the phase-diagram of a frustrated antiferromagnetic spin-1/2 ladder, with weak transverse and diagonal rung coupling. Our analysis focuses on a one-dimensional version of the model (i.e. a single two-leg ladder) where we consider two forms of dimerization on the legs: columnar dimers (CD) and staggered dimers (SD). We particularly examine the regime of parameters (corresponding to an intermediate XXZ anisotropy) where the leg-dimerization and the rung coupling terms are equally relevant. In both the CD and SD cases we find that the effective field theory describing the system is a self-dual sineGordon model, which favors ordering and the opening of a gap to excitations. The order parameter, which reflects the interplay between the leg and rung dimerization interactions, represents a crystal of 4-spin plaquettes on which longitudinal and transverse dimers are in a coherent superposition. Depending on the leg dimerization mode these plaquettes are closed or open, however both types spontaneously break reflection symmetry across the ladder. The closed plaquettes are stable, while the open plaquette-order is relatively fragile and the corresponding gap may be tuned to zero under extreme conditions. We further find that a first order transition occurs from the Plaquette order to a valence bond crystal (VBC) of dimers on the legs. It is suggestive that in a higher dimensional version of this system, this variety of distinct VBC states with comparable energies leads to the formation of domains. Effectively one-dimensional gapless spinon modes on domain boundaries can possibly account for the experimental observation of a spin-liquid behavior in a physical realization of the model.