Maßgeschneiderte Polyelektrolyt‐Mikrokapseln: von Multischichten zu smarten Kapseln

Peyratout, Claire; Dähne, Lars

doi:10.1002/ange.200300568

Cited by 92 publications

(45 citation statements)

References 151 publications

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“…[1,2] This development has led to a growing need for capsules with nanoengineered properties, including composition, structure, and permeability. A versatile and widely used method for preparing hollow capsules is based on layerby-layer (LbL) assembly.…”

mentioning

confidence: 99%

Exploiting the Directionality of DNA: Controlled Shrinkage of Engineered Oligonucleotide Capsules

Johnston

Caruso

2007

Angew Chem Int Ed

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mentioning

confidence: 99%

Exploiting the Directionality of DNA: Controlled Shrinkage of Engineered Oligonucleotide Capsules

Johnston

Caruso

2007

Angew Chem Int Ed

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“…[55] D) (TA/ PAH) 5 capsules incubated in FITC-dextran (2000 kDa) solutions at different pH values. [61] E) Loading of FITC-urease into (PSS/PAH) 4 capsules by changing the solvent polarity.…”

Section: Pre-and Postloadingmentioning

confidence: 99%

“…[3][4][5] These capsules are generated by sequential deposition of polymer layers from aqueous solutions onto a sacrificial template ( Figure 1). Almost any type of interaction (for example, electrostatics, hydrogen bonding, covalent bonding, specific recognition) can be used as the driving force for the assembly of the multilayer shell.…”

Section: Introductionmentioning

confidence: 99%

Polymeric Multilayer Capsules in Drug Delivery

et al. 2010

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Recent advances in medicine and biotechnology have prompted the need to develop nanoengineered delivery systems that can encapsulate a wide variety of novel therapeutics such as proteins, chemotherapeutics, and nucleic acids. Moreover, these delivery systems should be "intelligent", such that they can deliver their payload at a well-defined time, place, or after a specific stimulus. Polymeric multilayer capsules, made by layer-by-layer (LbL) coating of a sacrificial template followed by dissolution of the template, allow the design of microcapsules in aqueous conditions by using simple building blocks and assembly procedures, and provide a previously unmet control over the functionality of the microcapsules. Polymeric multilayer capsules have recently received increased interest from the life science community, and many interesting systems have appeared in the literature with biodegradable components and biospecific functionalities. In this Review we give an overview of the recent breakthroughs in their application for drug delivery.

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“…[2a, 4] It is commonly believed that perfect templates must fulfil three requirements: stability in the layer-by-layer (LBL) process, the condition of core disposal not affecting the structure and stability of the multilayer, and no residue of dissolved template. [5] In fact, the means of template decomposition has an important effect on the properties of poly-A C H T U N G T R E N N U N G electrolyte capsules. Organic templates of artificial polymers, such as MF and polystyrene (PS), need harsh conditions to remove the core, such as strong acids or organic solvents.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Size‐Controlled Acid‐Resistant Hybrid Calcium Carbonate Microparticles as Templates for Fabricating “Micelles‐Enhanced” Polyelectrolyte Capsules by the LBL Technique

Yue

Shen

2006

Chemistry A European J

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Size-controlled, low-dispersed calcium carbonate microparticles were synthesized in the presence of the amphiphilic block copolymer polystyrene-b-poly(acrylic acid) (PS-b-PAA) by modulating the concentration of block copolymer in the reactive system. This type of hybrid microparticles have acid-resistant properties. By investigating the aggregation behaviors of PS-b-PAA micelles by transmission electron microscopy (TEM), the mechanism of hybrid calcium carbonate formation illustrated that the block copolymer served not only as "pseudonuclei" for the growth of calcium carbonate nanocrystals, but also forms the supramicelle congeries, a spherical framework, as templates for calcium carbonate nanocrystal growth into hybrid CaCO(3) particles. Moreover, this pilot study shows that the hybrid microparticle is a novel candidate as a template for fabricating multilayer polyelectrolyte capsules, in which the block copolymer is retained within the capsule interior after core removal under soft conditions. This not only facilitates the encapsulation of special materials, but also provides "micelles-enhanced" polyelectrolyte capsules.

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Maßgeschneiderte Polyelektrolyt‐Mikrokapseln: von Multischichten zu smarten Kapseln

Cited by 92 publications

References 151 publications

Exploiting the Directionality of DNA: Controlled Shrinkage of Engineered Oligonucleotide Capsules

Exploiting the Directionality of DNA: Controlled Shrinkage of Engineered Oligonucleotide Capsules

Polymeric Multilayer Capsules in Drug Delivery

Synthesis of Size‐Controlled Acid‐Resistant Hybrid Calcium Carbonate Microparticles as Templates for Fabricating “Micelles‐Enhanced” Polyelectrolyte Capsules by the LBL Technique

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