By using generalized fractional derivative, the parametric generalized fractional Nikiforov-Uvarov (NU) method is introduced. The second-order parametric generalized differential equation is exactly solved in the fractional form. The obtained results are applied on the extended Cornell potential, the pesudoharmonic potential, the Mie potential, the Kratzer-Fues potential, the harmonic oscillator potential, the Morse potential, the Woods-Saxon potential, the Hulthen potential, the deformed Rosen-Morse potential and the P schl-Teller potential which play an important role in the fields of molecular and atomic physics. The special of classical cases are obtained from the fractional cases at which are agreement with recent works.