Massage during muscle unloading increases protein turnover in the massaged and non‐massaged, contralateral limb, but does not attenuate muscle atrophy

Kargl, Christopher; Sullivan, B. Patrick; Gavin, Timothy P.

doi:10.1111/apha.13497

Cited by 1 publication

(2 citation statements)

References 13 publications

(26 reference statements)

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“…Moreover, the mechanism of the mechanical stimuli from the extracellular matrix (ECM) is through the stimulation of integrin receptors’ functions via focal adhesion complexes (FACs) to the muscle cytoskeleton. Sequentially, activation of focal adhesion kinase (FAK) phosphorylation initiates progrowth signaling pathways within the muscle fiber [ 10 ]. For immune cells, they are recruited to play the critical role of adaptation for maintenance via response to massage stimuli in tissue homeostasis processes.…”

Section: Discussionmentioning

confidence: 99%

“…There are many inflammatory responses after the application of minimal pressure on muscles, including the migration of several immune cells to the affected area associated with a complex cell signaling system [ 7 ]. Complex interactions between skeletal muscle and the immune system regulate muscle regeneration [ 8 ] and stimulate effector T cells due to mechano-transduction [ 7 , 8 , 9 , 10 ]. Regarding functional immune cells, these T cells could be mechanosensing and activate immune responses [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Traditional Thai Massage Promoted Immunity in the Elderly via Attenuation of Senescent CD4+ T Cell Subsets: A Randomized Crossover Study

Sornkayasit

Jumnainsong

Phoksawat

et al. 2021

IJERPH

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The beneficial physiological effects of traditional Thai massage (TTM) have been previously documented. However, its effect on immune status, particularly in the elderly, has not been explored. This study aimed to investigate the effects of multiple rounds of TTM on senescent CD4+ T cell subsets in the elderly. The study recruited 12 volunteers (61–75 years), with senescent CD4+ T cell subsets, who received six weekly 1-h TTM sessions or rest, using a randomized controlled crossover study with a 30-day washout period. Flow cytometry analysis of surface markers and intracellular cytokine staining was performed. TTM could attenuate the senescent CD4+ T cell subsets, especially in CD4+28null NKG2D+ T cells (n = 12; p < 0.001). The participants were allocated into two groups (low < 2.75% or high ≥ 2.75%) depending on the number of CD4+28null NKG2D+ T cells. After receiving TTM over 6 sessions, the cell population of the high group had significantly decreased (p < 0.001), but the low group had no significant changes. In conclusion, multiple rounds of TTM may promote immunity through the attenuation of aberrant CD4+ T subsets. TTM may be provided as a complementary therapy to improve the immune system in elderly populations.

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Section: Discussionmentioning

confidence: 99%