Mass Treatment of Treponemal Diseases, With Particular Reference to Syphilis and Yaws

Abstract

The haemoglobin percentage fell to 26% (3.8 g.%) and the total leucocyte count to 10,600. Death occurred on July 20. Relevant Necropsy Findings.-The skin and all organs were pale, with many petechial haemorrhages. Several tough, pale nodules were present in the scalp, and there was a large haematoma on the extensor surface of the right forearm. The lymph nodes were all enlarged and pale. The spleen was enlarged, weighing 26 oz. (737 g.). On section it was red, soft, and coarsely granular. The liver weighed 92 oz. (2,608 g.), and was pale and firm on section. The right ankle-joint was opened. The synovial membrane, synovial fluid, and articular cartilage looked normal. Report on Histology.-"Sections of liver, spleen, lymph node, scalp nodule, skin haematoma, kidney, and small intestine show, in greater or less degree, infiltration by immature leukaemic cells. A portion of the synovial membrane of the left ankle shows infiltration by leukaemic stem cells. The cells have round or ovoid vesicular nuclei

Apple Down 152: A putative case of syphilis from sixth century AD Anglo‐Saxon England

“…Modern investigations also suggest that the endemic treponematoses have a very high prevalence (Guthe et al, 1953;Murray et al, 1956). The alternative, venereal syphilis, is usually acquired through sexual intercourse in adults, or as congenital syphilis in the child of an affected mother.…”

TMPRSS2/ERG fusion gene expression alters chemo‐ and radio‐responsiveness in cell culture models of androgen independent prostate cancer

“…Endemic syphilis is thought to arise in conditions of poor sanitation and hygiene, as might be present in small rural settlements (Turner, 1937). Modern investigations also suggest that the endemic treponematoses have a very high prevalence (Guthe et al, 1953; Murray et al, 1956). The alternative, venereal syphilis, is usually acquired through sexual intercourse in adults, or as congenital syphilis in the child of an affected mother.…”

Antibiotic Arrivals in Africa: A Case Study of Yaws and Syphilis in Malawi, Zimbabwe and Uganda

“…This makes clinical identification and diagnosis difficult and requires the additional use of specialised blood tests or darkfield microscopy (Mitjà, Šmajs, and Bassat 2013). There is thus considerable overlap between syphilis and other treponematoses (especially yaws, but also njovera, pinta, and bejel) in the medical literature of the mid-twentieth century (Guthe, Reynolds, and Krag 1953;Guthe and Reynolds 1951;Rein 1953). Indeed, yaws is also referred to as 'endemic syphilis' and, even though the two diseases were known to be caused by different microorganisms, there was scientific consensus that they responded to the same treatment and epidemiology, differing only in their clinical manifestations (Guthe, Reynolds, and Krag 1953;Hackett and Guthe 1956).…”