Mass transfer to microparticles in agitated systems

Armenante, Piero M.; Kirwan, Donald J.

doi:10.1016/0009-2509(89)85088-2

Cited by 185 publications

(129 citation statements)

References 28 publications

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“…However, there can be an effect of fluid deformation 39 as a direct effect of ambient vorticity. It is possible to derive a simple criteria to neglect hydrodynamics effects 40 :…”

Section: Precipitation Kineticsmentioning

confidence: 99%

A computational fluid dynamics study of supercritical antisolvent precipitation: Mixing effects on particle size

et al. 2011

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in Wiley Online Library (wileyonlinelibrary.com).Supercritical fluids have been extensively used for particle production of many natural and pharmaceutical substances providing useful alternatives for pharmaceutical and nutraceutical particulate system formulation. Among the different methods, the gas or supercritical antisolvent (GAS or SAS) process and its variants, have received a considerable interest due to the wide range of materials that can be micronized. Controlling particle formation in order to nucleate small particles is a key issue in GAS and SAS processes and this is directly related to mixing at all scales. In this work, we focus on numerical simulation of the process, emphasizing mixing modeling. Different mixing devices characterized by different nozzles are analyzed, to get an insight into mixing dynamics and its influence on the final particle size distribution. Results show that mixing is determinant in obtaining smallCorrespondence concerning this article should be addressed to J. Sierra-Pallares at jsierra@cfd1.eis.uva.es.

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“…However, there can be an effect of fluid deformation 39 as a direct effect of ambient vorticity. It is possible to derive a simple criteria to neglect hydrodynamics effects 40 :…”

Section: Precipitation Kineticsmentioning

confidence: 99%

A computational fluid dynamics study of supercritical antisolvent precipitation: Mixing effects on particle size

et al. 2011

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“…Regarding this coherence and referring to former work [43], this model was applied for the initial phase of adsorption only. According to the relation of Armenante and Kirwan [44] the mass transfer parameter k f and the Sherwood number Sh were calculated for the media investigated herein by assuming a stirred batch reactor with a volume of 10 mL at an impeller speed of 70 rpm. Values are listed in Table 6 as well.…”

Section: Uptake Kineticsmentioning

confidence: 99%

Adsorption of plasmid DNA on anion exchange chromatography media

Tarmann

Jungbauer²

2008

J of Separation Science

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Original PaperAdsorption of plasmid DNA on anion exchange chromatography media Anion exchange chromatography (AEC) is a useful and effective tool for DNA purification, but due to average pore sizes between 40 and 100 nm most AEC resins lack truly useful binding capacities for plasmid DNA (pDNA). Equilibrium binding capacities and uptake kinetics of AEC media including conventional media (Source 30 Q, Q Sepharose HP), a polymer grafted medium (Fractogel EMD DEAE (M)), media with large pores (Celbeads DEAE, PL SAX 4000 30 lm) and a monolithic medium (CIM-DEAE) were investigated by batch uptake or shallow bed experiments at two salt concentrations. Theoretical and experimental binding capacities suggest that the shape of the pDNA molecule can be described by a rod with a length to diameter ratio of 20:1 and that the molecule binds in upright position. The arrangement of DNA like a brush at the surface can be considered as entropy driven, kind of selfassembly process which is inherent to highly and uniformly charged DNA molecules. The initial phase of adsorption is very fast and levels off, associated with a change in mass transfer mechanism. Feed concentrations higher than 0.1 mg/mL pDNA pronounce this effect. Monolithic media showed the fastest adsorption rate and highest binding capacity with 13 mg pDNA per mL.

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“…The film mass transfer coefficient for small particles in agitated contactors can be estimated from the correlation in [32], which has been validated for protein adsorption in [33]. In practice, Sh > 10 and D 0 /e p D p is much smaller than one.…”

Section: Stirred Batch Adsorption [23±28]mentioning

confidence: 99%

Protein Mass Transfer Kinetics in Ion Exchange Media: Measurements and Interpretations

2005

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The paper gives a summary of successful methods for measuring protein mass transfer kinetics in ion exchange matrices along with models needed to interpret experimental results. Both macroscopic methods (isocratic elution, gradient elution, batch adsorption, frontal analysis) and microscopic methods are considered. In all cases the main focus is the determination of the effective intraparticle diffusivity in order to permit a comparison of different stationary phases and provide a basis for predicting chromatographic process performance. Experimental results for representative systems are evaluated alongside the experimental and modeling aspects. Practical criteria for the selection of experimental conditions and the application of different models are discussed along with the advantages and disadvantages of the various approaches.

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Mass transfer to microparticles in agitated systems

Cited by 185 publications

References 28 publications

A computational fluid dynamics study of supercritical antisolvent precipitation: Mixing effects on particle size

A computational fluid dynamics study of supercritical antisolvent precipitation: Mixing effects on particle size

Adsorption of plasmid DNA on anion exchange chromatography media

Protein Mass Transfer Kinetics in Ion Exchange Media: Measurements and Interpretations

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