A kinetic model for the RH desulfurization process was established based on the FactSage Macro Processing. The desulfurizer addition, the desulfurization reaction, the steel mixing, the flow circulation, and the desulfurizer floating during the RH refining process were considered in the model. Simulated results agreed well with measured results, indicating that the current model can be used to predict the desulfurization reactions during the RH refining process. The CaO activity increased with a higher CaO/Al2O3 ratio and a lower SiO2 content, which exhibited a similar tendency with the desulfurization ratio. It was indicated that it was necessary to increase the CaO activity in the desulfurizer to improve the desulfurization ratio. The S content in the molten steel decreased with time and a higher ratio of the powder blowing. The cost increased with time due to the refractory erosion and the steam consumption. The cost of the desulfurizer added by the powder blowing was lower than that of the gravity sinking.This article is protected by copyright. All rights reserved.