Mass transfer cell with vibrational mixing

Hančil, V.; Rod, Vladimír; Řeháková, M.

doi:10.1016/0300-9467(78)80023-9

Cited by 18 publications

(7 citation statements)

References 3 publications

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“…Proposed VC action includes transmission of oscillations from an external body surface to a thrombosed artery to cause mechanical agitation of clot and blood proximate the clot, while also potentially inducing a localized vasodilation response to the culprit vasculature. Turbulence induced at the blood clot interface is predictive (as shown in-vitro ) and inferable (in accordance with hydrodynamic mixing studies [Hancil V et al 1978, Neild A et al 2010, Oberti S et al 2009 ] to encourage systemic mixing of thrombolytics down an otherwise zero flow cerebral artery. Acoustic AIS therapy is generally problematic however as the cerebral arteries are mechanically shielded within the cranium.…”

Section: Introductionsupporting

confidence: 73%

Carotid Vibro-Compression: A Reperfusive Treatment for Acute Ischemic Stroke? Feasibility Data and a Potential Risk / Benefit Discussion in View to Animal Testing

Hoffmann¹,

Gill²

2017

J Exp Stroke Transl Med

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Slow uncertain reperfusion in Acute Ischemic Stroke (AIS) by intravenous thrombolysis has prompted search for alternative therapies. Pressure/flow disturbances from rapid compressions (20 -24 Hz) of a clotted flow tube remote from thrombosis site have shown to assist reflow. Carotid Vibro-Compression (VC), a potentially risky maneuver, may therefore enhance AIS reperfusion but verification is needed that vibro-compressions would transmit flow disturbances to the cerebral arteries. From a pool of 15 volunteers (mean age 48) carotid compressions (5 to 8 Hz, < = ~1 cm) (n =11) and vibration (30 Hz ~ 1 mm) (n = 10) were independently and together implemented with ipsilateral and contralateral Doppler flow monitoring of an intra-cranial artery. Doppler pulses from compressions were immediately demonstrated in all vessels (26 / 26) under all conditions. Pulses from vibration were observable in a majority of vessels (22 / 25), but signals were often challenging to obtain. Mean intra-cranial flow velocities trended to increase during compressions (46.1 ± 6 .4 cm/s vs. 44.0 ± 4.9 cm/s), but the difference was not statistically significant (p = 0.06). Carotid VC reliably transmits flow pulses to the cerebral vasculature, however vibration requires biofeedback to ensure device positioning. Carotid VC appears feasible for animal testing, but safety remains a major question.

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Section: Introductionsupporting

confidence: 73%

Carotid Vibro-Compression: A Reperfusive Treatment for Acute Ischemic Stroke? Feasibility Data and a Potential Risk / Benefit Discussion in View to Animal Testing

Hoffmann¹,

Gill²

2017

J Exp Stroke Transl Med

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“…In this work, three different reaction locations are possible: the organic phase, the aqueous phase, or the interphase. , If the reaction takes place in a bulk phase then the mole fractions of each reactant, which are available in this phase, are used in eq . In the case of a reaction at the interphase, the mole fractions of the reactants in different phases have to be used. − This kind of reaction can occur only in two-phase systems. For this reason, it is important to know the reaction location.…”

Section: Methodsmentioning

confidence: 99%

Purification of Terpenyl Amine by Reactive Extraction

Schulz

Bongard

Islam

et al. 2016

Ind. Eng. Chem. Res.

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This work analyzed the separation and purification of terpenyl amine by a reactive extraction in which an acid was used as complexing agent. Several different acids were investigated to form a water-soluble complex, but only carboxylic acids were found to be suitable for a reactive extraction of terpenyl amine. The best results according to yield and selectivity were found for acetic acid. Moreover, there was no formation of an emulsion using the acetic acid. The reaction mechanism and reaction location were determined to characterize this complexation reaction of acetic acid with terpenyl amine. The main mechanism was the Hbond formation at the interface between the organic and aqueous phases. Finally, the pseudomole-fraction-based equilibrium constant of 4.26 was estimated with a complex factor of 1 to 4.26 with selectivity above 98%.

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“…The cell was shown earlier in Figure 1. Instead of the usual rotators, two vibrating plates fixed on a common rod, which is driven by a loudspeaker, provide the mixing of both phases (Hancil et al, 1978). A digital frequency generator, which can produce sinus waves with a frequency of 0 to 100 Hz, is used as the power supply for the loudspeaker.…”

Section: Experimental Studiesmentioning

confidence: 99%