Abstract:Using tandem mass spectroscopy (MS), we identified 3646 unique sequences among peptides eluted from purified Kd and Dd MHC I molecules of the BALB/c fibrosarcoma Meth A. These peptides were cross-referenced with the output of neoepitopes predicted for this tumor by our prediction pipeline CCCP (Cross Consensus Calling Platform). Eleven (11) of the eluted peptides were identified as neoepitopes and eight neoepitopes (of 11) were confirmed by targeted MS.
Each neoepitope was used to immunize BALB/… Show more
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