Mass spectrometry studies of <i>Lycopodium</i> alkaloid sauroine

Vallejo, Mariana Guadalupe; Cifuente, Diego Alberto; Cecati, Francisco Miguel; Ortega, Marı́a Gabriela; Cabrera, José Luis; Martı́n, Victor S.; Tonn, Carlos E.; Agnese, Alicia Mariel; Ardanaz, C. E.

doi:10.1002/rcm.6380

Cited by 3 publications

(3 citation statements)

References 11 publications

(6 reference statements)

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“…In view of this situation, the main ESI‐MS fragmentation mechanisms of a series of antitumor agents containing the tetrahydroquinoline scaffold, which included eight furo[3,2‐ c ]tetrahydroquinoline and six pyrano[3,2‐ c ]tetrahydroquinoline derivatives (Tables and ), were investigated. First, moderate‐resolution and accurate mass measurements were achieved with an ESI‐Q‐TOF mass spectrometer to acquire the elemental compositions of the fragment ions . Second, multistage electrospray ionization (ESI‐MS n ) experiments in an ion trap instrument allowed us to understand the relationship between precursor and product ions .…”

Section: The Structures and Main Fragmentation Pathways Of Furo[32‐cmentioning

confidence: 99%

Analysis of furo[3,2‐c]tetrahydroquinoline and pyrano[3,2‐c]tetrahydroquinoline derivatives as antitumor agents and their metabolites by liquid chromatography/electrospray ionization tandem mass spectrometry

Hou

Luo

et al. 2013

Rapid Comm Mass Spectrometry

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Section: The Structures and Main Fragmentation Pathways Of Furo[32‐cmentioning

confidence: 99%

Analysis of furo[3,2‐c]tetrahydroquinoline and pyrano[3,2‐c]tetrahydroquinoline derivatives as antitumor agents and their metabolites by liquid chromatography/electrospray ionization tandem mass spectrometry

Hou

Luo

et al. 2013

Rapid Comm Mass Spectrometry

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“…To investigate LAs from a plant species, the traditional phytochemical approaches usually involved multistep isolation and structural elucidation of pure compounds from a plant of interest, which are often tedious, complex, and time-consuming [ 3 ]. Because of the excellent performance on simultaneous separation and identification of multicomponent mixtures with complex background, chromatography based separation techniques (i.e., GC and LC) coupled with various detectors, such as mass spectrometry (MS), were developed as useful tools in most cases [ 12 ]. Since most LAs from plants are nonvolatile, LC techniques, for example, high-performance LC (HPLC) and ultraperformance LC (UPLC), were preferred over GC in obtaining the fingerprint profiles of LAs [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Components and Anti‐HepG2 Activity Comparison of Lycopodium Alkaloids from Four Geographic Origins

Tian

Chen

2016

Evidence-Based Complementary and Alternative Medicine

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Lycopodium japonicum Thunb. has attracted great interests due to its rich alkaloids with significant anticancer activity. However, significant chemical differences often exist in a plant species from different geographic origins and affect its quality and bioactivities. Thus, it is urgent to reveal their chemical and biological distinctions at the molecular level. In this context, a comparative chemical analysis of LAs using HPLC-UV-ESI-MS/MS was firstly conducted and resulted in the detection of 46 LAs, 28 of which were identified, and a series of unique LAs markers, such as peaks 2, 9, 10, and 11, were further found to be characteristic LAs and selected as markers from four different origins for their quality control. In parallel, the comparative bioactivity assay revealed that the total LAs from Hubei province exhibited much higher inhibitory rate at 65.95% against HepG2 cells than those at 26.72%, 20.26%, and 33.62% for Kenya, Guangxi province, and Zhejiang province in China, respectively. To this end, significant chemical fingerprinting differences and discrepancies in bioactivity of LAs were explored firstly, which could provide valuable information for quality control and further activity studies on LAs from different sources and promote their better pharmaceutical applications in the future as well.

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“…On the other hand, we had previously reported the mass spectrometric study of sauroine . In this work, we focus on the application of mass spectrometry to support the structural determination of the lycodine‐type Lycopodium alkaloids: sauroxine ( 1 ) and N ‐demethylsauroxine ( 2 ) (Fig.…”

mentioning

confidence: 99%

Mass spectrometry studies of lycodine‐type Lycopodium alkaloids: sauroxine and N‐demethylsauroxine

Cifuente

Vallejo

Ortega

et al. 2014

Rapid Comm Mass Spectrometry

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Mass spectrometry studies of Lycopodium alkaloid sauroine

Cited by 3 publications

References 11 publications

Analysis of furo[3,2‐c]tetrahydroquinoline and pyrano[3,2‐c]tetrahydroquinoline derivatives as antitumor agents and their metabolites by liquid chromatography/electrospray ionization tandem mass spectrometry

Analysis of furo[3,2‐c]tetrahydroquinoline and pyrano[3,2‐c]tetrahydroquinoline derivatives as antitumor agents and their metabolites by liquid chromatography/electrospray ionization tandem mass spectrometry

Components and Anti‐HepG2 Activity Comparison of Lycopodium Alkaloids from Four Geographic Origins

Mass spectrometry studies of lycodine‐type Lycopodium alkaloids: sauroxine and N‐demethylsauroxine

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