Mass Spectrometry Parameters Optimization for the 46 Multiclass Pesticides Determination in Strawberries with Gas Chromatography Ion-Trap Tandem Mass Spectrometry

Fernandes, Virgínia Cruz; Vera, José; Domingues, Valentina F.; Silva, Luís M. S.; Mateus, Nuno; Delerue–Matos, Cristina

doi:10.1007/s13361-012-0488-6

Cited by 15 publications

(2 citation statements)

References 21 publications

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“…The MS/ MS conditions were fixed for each compound, trying to select as precursor ion the one with the highest m/z ratio and abundance. [21] Results and discussion…”

Section: Gas Chromatography-tandem Mass Spectrometrymentioning

confidence: 99%

Eruca sativa: Benefits as antioxidants source versus risks of already banned pesticides

Maia

Correia-Sá

Coelho

et al. 2015

Journal of Environmental Science and Health, Part B

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Eruca sativa (rocket salad) has been intensely consumed all over the world, insomuch as, this work was undertaken to evaluate the antioxidant status and the environmental contamination (positive and negative nutritional contribution) of leaves and stems from this vegetable. Antioxidant capacity of rocket salad was assessed by mean of optical methods, such as the total phenolic content (TPC), reducing power assay and DPPH radical scavenging activity. The extent of the environmental contamination was reached through the quantification of thirteen organochlorine pesticides (OCP) by using gas chromatography coupled with electron-capture detector (GC-ECD) and compound confirmations employing gas chromatography tandem mass-spectrometry (GC-MS/MS). The OCP residues were extracted by using Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) methodology.The extent of the environmental contamination was reached through the quantification of thirteen OCP by using gas chromatography coupled with electron-capture detector (GC-ECD) and compound confirmations employing GC-MS/MS. The OCP residues were extracted by using Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) methodology. This demonstrated that leaves presented more antioxidant activity than stems, emphasizing that leaves contained six times more polyphenolic compounds than stems. In what concerns the OCP occurrence, the average recoveries obtained at the three levels tested (40, 60 and 80 µg kg(-1)) ranged from 55% to 149% with a relative standard deviation of 11%, (except hexachrorobenzene). Three vegetables samples were collected from supermarkets and analysed following this study. According to data, only one sample achieved 16.21 of β-hexachlorocyclohexane, confirmed by GC-MS/MS. About OCP quantification, the data indicated that only one sample achieved 16.21 µg kg(-1) of β-hexachlorocyclohexane, confirmed by GC-MS/MS, being the QuEChERS a good choice for the of OCPs extraction. Furthermore, the leaves consumption guaranty higher levels of antioxidants than stems.

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“…The MS/ MS conditions were fixed for each compound, trying to select as precursor ion the one with the highest m/z ratio and abundance. [21] Results and discussion…”

Section: Gas Chromatography-tandem Mass Spectrometrymentioning

confidence: 99%

Eruca sativa: Benefits as antioxidants source versus risks of already banned pesticides

Maia

Correia-Sá

Coelho

et al. 2015

Journal of Environmental Science and Health, Part B

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“…In particular, it is important to identify the factors that influence analyte signal intensity and quality [12,13]. In 2010, Dillon et al [14] developed a methodology for the performance assessment of electrospray ionization systems applied to volatile organic compounds determination.…”

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confidence: 99%

Optimization of the Ion Source-Mass Spectrometry Parameters in Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals Analysis by a Design of Experiments Approach

Paíga

Silva

Delerue–Matos

2016

J. Am. Soc. Mass Spectrom.

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Abstract. The flow rates of drying and nebulizing gas, heat block and desolvation line temperatures and interface voltage are potential electrospray ionization parameters as they may enhance sensitivity of the mass spectrometer. The conditions that give higher sensitivity of 13 pharmaceuticals were explored. First, Plackett-Burman design was implemented to screen significant factors, and it was concluded that interface voltage and nebulizing gas flow were the only factors that influence the intensity signal for all pharmaceuticals. This fractionated factorial design was projected to set a full 2 2 factorial design with center points. The lack-of-fit test proved to be significant. Then, a central composite face-centered design was conducted. Finally, a stepwise multiple linear regression and subsequently an optimization problem solving were carried out. Two main drug clusters were found concerning the signal intensities of all runs of the augmented factorial design. pAminophenol, salicylic acid, and nimesulide constitute one cluster as a result of showing much higher sensitivity than the remaining drugs. The other cluster is more homogeneous with some sub-clusters comprising one pharmaceutical and its respective metabolite. It was observed that instrumental signal increased when both significant factors increased with maximum signal occurring when both codified factors are set at level +1. It was also found that, for most of the pharmaceuticals, interface voltage influences the intensity of the instrument more than the nebulizing gas flowrate. The only exceptions refer to nimesulide where the relative importance of the factors is reversed and still salicylic acid where both factors equally influence the instrumental signal.

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Extraction Procedures and Chromatography of Pesticides Residues in Strawberries

Fernandes

Maia

Correia-Sá

et al. 2020

Sustainable Agriculture Reviews

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Mass Spectrometry Parameters Optimization for the 46 Multiclass Pesticides Determination in Strawberries with Gas Chromatography Ion-Trap Tandem Mass Spectrometry

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Cited by 15 publications

References 21 publications

Eruca sativa: Benefits as antioxidants source versus risks of already banned pesticides

Eruca sativa: Benefits as antioxidants source versus risks of already banned pesticides

Optimization of the Ion Source-Mass Spectrometry Parameters in Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals Analysis by a Design of Experiments Approach

Extraction Procedures and Chromatography of Pesticides Residues in Strawberries

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