2021
DOI: 10.1021/acs.chemrev.1c00386
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Mass Spectrometry of Nucleic Acid Noncovalent Complexes

Abstract: Nucleic acids have been among the first targets for antitumor drugs and antibiotics, and with the unveiling of new biological roles in regulation of gene expression, specific DNA and RNA structures have become very attractive targets, especially when the corresponding proteins are undruggable. Biophysical assays to test target structure and ligand binding stoichiometry, affinity, specificity and binding modes are part of the drug development pipeline. Mass spectrometry offers unique advantages as a biophysical… Show more

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Cited by 47 publications
(75 citation statements)
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References 1,212 publications
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“…Our group recently reviewed mass spectrometry of nucleic acid complexes. 19 This more personal account highlights key novel insights generated through our effort in bridging the fields of nucleic acids biophysics and fundamental mass spectrometry. quadruplexes focused on sequences obeying this rule, such as…”
Section: ■ Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Our group recently reviewed mass spectrometry of nucleic acid complexes. 19 This more personal account highlights key novel insights generated through our effort in bridging the fields of nucleic acids biophysics and fundamental mass spectrometry. quadruplexes focused on sequences obeying this rule, such as…”
Section: ■ Introductionmentioning
confidence: 99%
“…As a result, in our hands, advances in nucleic acids biophysics have been constantly intertwined with advances in measurement sciences. Our group recently reviewed mass spectrometry of nucleic acid complexes . This more personal account highlights key novel insights generated through our effort in bridging the fields of nucleic acids biophysics and fundamental mass spectrometry.…”
Section: Introductionmentioning
confidence: 99%
“…Mass spectrometry analysis of intact polyanionic nucleic acids has nowadays acquired sufficient maturity to be considered as a method of choice for the structural investigation of nucleic acids, including nucleic acids complexed to dendrimers . In particular, ion mobility spectrometry (IMS) experiments represent an invaluable analytical method to generate structural data on gas-phase ions .…”
Section: Introductionmentioning
confidence: 99%
“…The low ionisation efficiency and poor mass spectrometry detection sensitivity of single and double chains of nucleic acids have greatly limited their application [ 14 , 15 ]. In a recent study, DNA detection probes were labelled with rare earth elements; these were hybridised with target DNA chains on magnetic beads, with each element corresponding to different target DNA chains [ 16 ].…”
Section: Introductionmentioning
confidence: 99%