Mass Spectrometry of Nanoparticles is Different

Liang, Chao-Kai; Eller, Michael J.; Verkhoturov, Stanislav V.; Schweikert, E. A.

doi:10.1007/s13361-015-1151-9

Cited by 11 publications

(6 citation statements)

References 26 publications

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“…However, it is necessary to have a well-working methodology to deconvolute the analytical results. 202 Blanc et al used SIMS to analyse the composition of dielectric NPs localized in a silica glass matrix in the core of optical fibers. They performed SIMS imaging at high spatial resolution (NanoSIMS 50L) and their goal was to gain more understanding on the spectroscopic properties of the luminescent ions in these fibers.…”

Section: X-ray-based Techniquesmentioning

confidence: 99%

Characterization techniques for nanoparticles: comparison and complementarity upon studying nanoparticle properties

2018

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Nanostructures have attracted huge interest as a rapidly growing class of materials for many applications. Several techniques have been used to characterize the size, crystal structure, elemental composition and a variety of other physical properties of nanoparticles. In several cases, there are physical properties that can be evaluated by more than one technique. Different strengths and limitations of each technique complicate the choice of the most suitable method, while often a combinatorial characterization approach is needed. In addition, given that the significance of nanoparticles in basic research and applications is constantly increasing, it is necessary that researchers from separate fields overcome the challenges in the reproducible and reliable characterization of nanomaterials, after their synthesis and further process (e.g. annealing) stages. The principal objective of this review is to summarize the present knowledge on the use, advances, advantages and weaknesses of a large number of experimental techniques that are available for the characterization of nanoparticles. Different characterization techniques are classified according to the concept/group of the technique used, the information they can provide, or the materials that they are destined for. We describe the main characteristics of the techniques and their operation principles and we give various examples of their use, presenting them in a comparative mode, when possible, in relation to the property studied in each case.

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Section: X-ray-based Techniquesmentioning

confidence: 99%

Characterization techniques for nanoparticles: comparison and complementarity upon studying nanoparticle properties

2018

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“…8 Growing awareness has led to a sharp increase in NP studies and development of methods for the measurement of NPs. 9 Methods such as atomic-force microscopy (AFM), 10 scanning electron microscopy (SEM), 11 secondary-ion mass spectrometry (SIMS), 12 transmission electron microscopy (TEM), dynamic light scattering (DLS), 13,14 and single particle–inductively coupled plasma mass spectrometry (SP-ICPMS) are frequently used to characterize NPs.…”

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confidence: 99%

Nanoparticle Analysis in Biomaterials Using Laser Ablation−Single Particle−Inductively Coupled Plasma Mass Spectrometry

et al. 2019

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In the past decade, the development of single particle–inductively coupled plasma mass spectrometry (SP-ICPMS) has revolutionized the field of nanometallomics. Besides differentiation between dissolved and particulate metal signals, SP-ICPMS can quantify the nanoparticle (NP) number concentration and size. Because SP-ICPMS is limited to characterization of NPs in solution, we show how solid sampling by laser ablation (LA) adds spatial-resolution characteristics for localized NP analysis in biomaterials. Using custom-made gelatin standards doped with dissolved gold and commercial or synthesized gold nanoparticles, LA-SP-ICPMS conditions such as laser fluence, beam size, and dwell time were optimized for NP analysis to minimize NP degradation, peak overlap, and interferences from dissolved gold. A data-processing algorithm to retrieve the NP number concentration and size was developed for this purpose. As a proof-of-concept, a sunflower-root-sample cross-section, originating from a sunflower plant exposed to gold NPs, was successfully imaged using the optimized LA-SP-ICPMS conditions for localized NP characterization.

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“…It has been stated that "mass spectrometry of nanoparticles is different". 45 Indeed, for the type of objects examined here, the secondary ion emission is size-dependent and impacts are not all equivalent. Yet we demonstrate that NP-SIMS in the eventby-event bombardment/detection mode allows for accurate analysis of nanoassemblies.…”

Section: ■ Conclusionmentioning

confidence: 91%

Nanoprojectile Secondary Ion Mass Spectrometry for Nanometrology of Nanoparticles and Their Interfaces

et al. 2022

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Nanoscale molecular characterization plays a crucial role in enhancing our insights into fundamental and materials processes occurring at the nanoscale. However, for many traditional techniques, measurements on different ensembles are mixed and the analytical result reflects the average surface composition or arrangement. Advances in nanometrologies that allow for measurements to be differentiated based on the chemical environment examined are critical for accurate analysis. Here, we present a variant of secondary ion mass spectrometry, SIMS, termed nanoprojectile SIMS, NP-SIMS, capable of nanoscale molecular analysis. The technique examines the sample with a suite, 106–107, of individual gold nanoprojectiles (e.g., Au400 4+) which stochastically probe the surface. Analysis of coemitted ions from each impact allows for the inspection of colocalized moieties within the ejected volume of a single projectile impact (10–15 nm in diameter). If some of these 106–107 measurements arise from nanodomains of similar composition, data can be grouped based on the detected secondary ions. We applied the method to examine a mixture of three different-sized nanoparticles with identical metal cores (3–5 nm in diameter), differing in the length of the attached ligand (decanetiol, tetradecanethiol, and hexadecanethiol). Using NP-SIMS, we determined the relative abundance of the three particles on the surface and isolated measurements based on the impact parameter between the impacting nanoprojectile and the surface particle, demonstrating that measurements occurring near the center of the particle can be differentiated from those at the particle–particle and particle–substrate interfaces. The results suggest that the described methodology is well-suited for molecular analysis of nanoassemblies and may be applied for tracking defects. Here we demonstrate that, using NP-SIMS, ensemble averaging can be avoided and molecular analysis can be undertaken at a scale below 5 nm, allowing for nanoscale molecular analysis of nano-objects and their interfaces.

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Mass Spectrometry of Nanoparticles is Different

Cited by 11 publications

References 26 publications

Characterization techniques for nanoparticles: comparison and complementarity upon studying nanoparticle properties

Characterization techniques for nanoparticles: comparison and complementarity upon studying nanoparticle properties

Nanoparticle Analysis in Biomaterials Using Laser Ablation−Single Particle−Inductively Coupled Plasma Mass Spectrometry

Nanoprojectile Secondary Ion Mass Spectrometry for Nanometrology of Nanoparticles and Their Interfaces

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