Mass spectrometry imaging protocol for spatial mapping of lipids, N‐glycans and peptides in murine lung tissue
Yuen T. Ngai,
Matthew T. Briggs,
Parul Mittal
et al.
Abstract:RationaleThe application of matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI‐MSI) to murine lungs is challenging due to the spongy nature of the tissue. Lungs consist of interconnected air sacs (alveoli) lined by a single layer of flattened epithelial cells, which requires inflation to maintain its natural structure. Therefore, a protocol that is compatible with both lung instillation and high spatial resolution is essential to enable multi‐omic studies on murine lung disease models… Show more
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