Mass spectrometry‐based retina proteomics

Prókai, László; Zaman, Khadiza; Prókai-Tátrai, Katalin

doi:10.1002/mas.21786

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2023

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Cited by 2 publications

References 272 publications

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Relevance of Multi-Omics Approach for Future Pandemic Preparedness and Response

Rana,

Sharma,

Kumar

2023

Preparedness for Future Pandemics

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Relevance of Multi-Omics Approach for Future Pandemic Preparedness and Response

Rana,

Sharma,

Kumar

2023

Preparedness for Future Pandemics

View full text Add to dashboard Cite

Proteomics-Based Identification of Retinal Protein Networks Impacted by Elevated Intraocular Pressure in the Hypertonic Saline Injection Model of Experimental Glaucoma

Zaman

Nguyen

Prókai-Tátrai

et al. 2023

IJMS

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Elevated intraocular pressure is considered a major cause of glaucomatous retinal neurodegeneration. To facilitate a better understanding of the underlying molecular processes and mechanisms, we report a study focusing on alterations of the retina proteome by induced ocular hypertension in a rat model of the disease. Glaucomatous processes were modeled through sclerosing the aqueous outflow routes of the eyes by hypertonic saline injections into an episcleral vein. Mass spectrometry-based quantitative retina proteomics using a label-free shotgun methodology identified over 200 proteins significantly affected by ocular hypertension. Various facets of glaucomatous pathophysiology were revealed through the organization of the findings into protein interaction networks and by pathway analyses. Concentrating on retinal neurodegeneration as a characteristic process of the disease, elevated intraocular pressure-induced alterations in the expression of selected proteins were verified by targeted proteomics based on nanoflow liquid chromatography coupled with nano-electrospray ionization tandem mass spectrometry using the parallel reaction monitoring method of data acquisition. Acquired raw data are shared through deposition to the ProteomeXchange Consortium (PXD042729), making a retina proteomics dataset on the selected animal model of glaucoma available for the first time.

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Mass spectrometry‐based retina proteomics

Cited by 2 publications

References 272 publications

Relevance of Multi-Omics Approach for Future Pandemic Preparedness and Response

Relevance of Multi-Omics Approach for Future Pandemic Preparedness and Response

Proteomics-Based Identification of Retinal Protein Networks Impacted by Elevated Intraocular Pressure in the Hypertonic Saline Injection Model of Experimental Glaucoma

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