Mass spectrometry—applications in science and engineering. Wiley, New York, 1986. $72.50 ISBN 0-471-09236-3

White, F. A.; Wood, G. M.; Olthoff, James K.

doi:10.1002/bms.1200150811

Cited by 6 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mass resolution is defined as M/DM where M is the average mass of two profiles of equal height with a 10% valley between them. 19 Figure 6(a) shows a profile calculated by the PGM and Fig. 6 (b) the same profile in the tune display for the [F 1] ions from C 3 H 8 N formed from chlorpromazine with a mass resolution of 12 700.…”

Section: Examining Profiles At a Single Nominal Massmentioning

confidence: 97%

Determination of elemental compositions by high resolution mass spectrometry without mass calibrants

Grange

Sovocool

1999

Rapid Commun. Mass Spectrom.

View full text Add to dashboard Cite

Perfluorokerosene can almost always be used as the mass calibrant for ions produced through electron impact ionization of compounds introduced into a mass spectrometer in the gas phase. Unfortunately, no completely universal calibrant is available for ions created by electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI) of analytes introduced into a mass spectrometer in the liquid phase. ESI and APCI generally provide less sensitivity than electron impact ionization of compounds introduced in the gas phase and a portion of the weaker total signal must arise from calibrant ions. Solvent conditions must be found that provide ions from both the calibrant and analytes, or an alternative flow to the ionization region must be provided for the calibrant solution. These problems were avoided by developing a methodology to determine elemental compositions of ions without using mass calibrants. The methodology utilizes the ability of double focusing mass spectrometers to accurately measure relative abundances of ions and exact mass differences between ions. This approach should simplify analyses of environmental samples that contain mixtures of compounds not amenable to gas chromatography or volatilization from a probe. From one to five steps were used. First, from mass peak profiles of the molecular ion or protonated molecular ion, [M] , and two fragment ions resulting from known neutral losses using theoretical exact masses based on each [M] composition as the center masses of the three profiles. When the calibration mass option was not used in the multiple ion detector (MID) descriptor, three centered profiles were obtained only for the correct composition. This methodology was demonstrated for seven compounds with molecular weights between 159 and 318 Da. For the lowest-mass compound, only the first step was required to obtain the correct composition of [M] while, for the other compounds, two or more steps were needed.

show abstract

Section: Examining Profiles At a Single Nominal Massmentioning

confidence: 97%

Determination of elemental compositions by high resolution mass spectrometry without mass calibrants

Grange

Sovocool

1999

Rapid Commun. Mass Spectrom.

View full text Add to dashboard Cite

show abstract

“…Finally, there have been a few reported process applications of thermal ionization, wherein species are ionized by impact with a hot surface of low work function. 37 Primarily a means of elemental analysis, thermal ionization has been used to continuously monitor airborne radionuclides, even when incorporated into microparticles. 38 Selectivity can be gained by pretreating the hot filament, as reported for selective monitoring of I 2 in process off-gas using specially treated rhenium filaments for negative ion PMS.…”

Section: Instrumentationmentioning

confidence: 99%

“…Finally, there have been a few reported process applications of thermal ionization , wherein species are ionized by impact with a hot surface of low work function . Primarily a means of elemental analysis, thermal ionization has been used to continuously monitor airborne radionuclides, even when incorporated into microparticles .…”

Section: Instrumentationmentioning

confidence: 99%

On-Line Mass Spectrometry: A Faster Route to Process Monitoring and Control

Cook

Bennett

Haddix

1999

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

A critical review of on-line mass spectrometry is presented, illustrating instrumentation, data treatment, and applications drawn from both control and research environments. Both direct and membrane inlets are included. The discussion of instrumentation focuses on commercially available options, although some research options that offer promise for future process applications are also mentioned briefly. Special considerations attendant upon the high-precision measurements needed for simultaneous analysis and continuous process control are emphasized. Applications illustrate a range of problems benefitting from rapid, simultaneous analysis of volatiles.

show abstract

“…The advent of tandem mass spectrometry (MS 2 , or MS/MS), specifically collision-induced dissociation (CID), was a critical step in the development of mass spectrometry. , With MS 2 capabilities, a precursor ion can be separated, isolated, and fragmented, generating product ions from which the precursor ion structure can be deduced. , Tandem mass spectrometry is useful for ion structure elucidation, but it is also important in compound identification, quantitation, and reaction monitoring . Not only is MS 2 a workhorse for organic chemists, it is a critical tool for the fields of “omics,” , forensics, , and environmental monitoring. , …”

mentioning

confidence: 99%

Multigenerational Collision-Induced Dissociation for Characterization of Organic Compounds

2016

View full text Add to dashboard Cite

There are many cases in which limited information is obtained from a single stage of tandem mass spectrometry (MS or MS/MS). For example, isomeric cathinones give similar product ion MS spectra, but they can be differentiated by their unique MS fragments. Other drugs such as oxycodone and noroxycodone lose water in a single-stage tandem mass spectrometry experiment but give rich structural information in subsequent stages, as do many peptides. Here we utilize multigenerational collision-induced dissociation (CID) on a miniature mass spectrometer and emphasize useful applications. Unique fragmentation patterns consisting of several generations of fragment ions are obtained in these multigenerational spectra, allowing discrimination of cathinone isomers and structural characterization of small molecules, including drugs and peptides, all using a single sequence of ion injection, isolation, and mass scanning.

show abstract

Mass spectrometry—applications in science and engineering. Wiley, New York, 1986. $72.50 ISBN 0-471-09236-3

Cited by 6 publications

References 0 publications

Determination of elemental compositions by high resolution mass spectrometry without mass calibrants

Determination of elemental compositions by high resolution mass spectrometry without mass calibrants

On-Line Mass Spectrometry: A Faster Route to Process Monitoring and Control

Multigenerational Collision-Induced Dissociation for Characterization of Organic Compounds

Contact Info

Product

Resources

About