Mass Spectrometry and Eicosanoid Analysis

Measurement of Low Picomolar Levels of Triamcinolone Acetonide in Human Bronchoalveolar Lavage Fluid by Gas Chromatography-Electron-Capture Negative-Ion Mass Spectrometry

“…Numerous studies have shown that the detection limits of compounds lacking inherent electron-capture properties via combined gas chromatography-electroncapture mass spectrometric techniques can be greatly enhanced via conversion of the analytes of interest to electron-capture derivatives (13)(14)(15)(16)(17)(18)(19)(20). Enhancement of the detection limits of the analytes via conversion to electron-capture derivatives has facilitated numerous studies that previously could not have been performed, particularly clinical studies in which the volume of biological fluids and/or the quantity and number of tissue samples that can be taken are limited in consideration for the health and well being of human subjects (21)(22)(23)(24).…”