Mass Spectrometry Analysis of Urinary Methylmalonic Acid to Screen for Metabolic Vitamin B
            <sub>12</sub>
            Deficiency in Older Adults

Boutin, Michel; Presse, Nancy; Martineau, Tristan; Perreault, Audrey; Gaudreau, Pierrette; Auray‐Blais, Christiane

doi:10.4155/bio-2020-0106

Cited by 9 publications

(4 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The latter one at elevated levels in blood or urine may indicate certain metabolic disorders, such as vitamin B12 deficiency. 29 Other compounds of interest found in the extract were corchorifatty acid F and l -malic acid. As reported by Souza et al , 30 these moieties, identified in K. daigremontiana plants, have potential as bioactive agents, shedding light on their safety and pharmacological potential.…”

Section: Resultsmentioning

confidence: 99%

Exploiting residual cocoa biomass to extract advanced materials as building blocks for manufacturing nanoparticles aimed at alleviating formation-induced oxidative stress on human dermal fibroblasts

Girón-Hernández,

Rodríguez,

Corbezzolo

et al. 2024

Nanoscale Adv.

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Exploiting residual cocoa biomass to extract advanced materials as building blocks for manufacturing nanoparticles aimed at alleviating formation-induced oxidative stress on human dermal fibroblasts

Girón-Hernández,

Rodríguez,

Corbezzolo

et al. 2024

Nanoscale Adv.

View full text Add to dashboard Cite

show abstract

“…Methylmalonic acid was determined directly in the diluted urine samples by UPLC-MS/MS, following the procedure described by Boutin et al, (2020) [42]. In addition, a good chromatographic separation was obtained between the succinic and methylmalonic acids.…”

Section: Water-soluble Vitamins and Vitamin-b12-associated Biomarkersmentioning

confidence: 99%

Human Milk Composition and Nutritional Status of Omnivore Human Milk Donors Compared with Vegetarian/Vegan Lactating Mothers

et al. 2023

View full text Add to dashboard Cite

Women of childbearing age in Western societies are increasingly adopting vegetarian diets. These women are sometimes rejected as milk donors, but little about the composition of their milk is known. The present study aimed to compare the intake, nutritional status, and nutritional composition of human milk from omnivore human milk donors (Donors) and vegetarian/vegan lactating mothers (Veg). Milk, blood, and urine samples from 92 Donors and 20 Veg were used to determine their fatty acid profiles, as well as vitamins and minerals. In a representative sample of both groups, we also determined the lipid class profile as a distribution of neutral and polar lipids, the molecular species of triacylglycerols, and the relative composition of phospholipids in their milk. A dietary assessment was conducted with a five-day dietary record (while considering the intake of supplements). We highlight the following results, expressed as the mean (SE), for the Veg vs. Donors: (1) Their docosahexaenoic acid (DHA) intake was 0.11 (0.03) vs. 0.38 (0.03) g/day; the plasma DHA was 0.37 (0.07) vs. 0.83 (0.06)%; and the milk DHA was 0.15 (0.04) vs. 0.33 (0.02)%. (2) Their milk B12 levels were 545.69 (20.49) vs. 482.89 (4.11) pM; 85% of the Veg reported taking B12 supplements (mean dose: 312.1 mcg/day); and the Veg group showed no differences with Donors in terms of total daily intake or plasma B12. (3) Their milk phosphatidylcholine levels were 26.88 (0.67) vs. 30.55 (1.10)%. (4) Their milk iodine levels were 126.42 (13.37) vs. 159.22 (5.13) mcg/L. In conclusion, the Vegs’ milk was shown to be different from the Donors’ milk, mainly due to its low DHA content, which is concerning. However, raising awareness and ensuring proper supplementation could bridge this gap, as has already been achieved for cobalamin.

show abstract

“…Завершает TOP-16 самых интересных исследований по лечению раннего РМЖ анализ влияния метилмалоновой кислоты (ММК) на старческую слабость у больных ранним РМЖ [22]. Интерес к изучению роли ММК вырос в последние годы в связи с накоплением данных о ее связи с возрастом и прогрессированием злокачественных новообразований [23,24]. ММК является компонентом цикла Кребса, проходит превращение с участием витамина B 12 , в связи с чем ее накопление в сыворотке крови говорит о дефиците данного витамина у пациентов моложе 70 лет.…”

Section: новости в лечении раннего рмж: особые клинические ситуацииunclassified

“…ММК является компонентом цикла Кребса, проходит превращение с участием витамина B 12 , в связи с чем ее накопление в сыворотке крови говорит о дефиците данного витамина у пациентов моложе 70 лет. Однако прямая связь высокой концентрации ММК с дефицитом витамина B 12 отсутствует у пожи-лых людей старше 70 лет [23]. При этом показано влияние ММК на репрограммирование транскрипции опухолевых клеток и приобретении ими агрессивного фенотипа, что может объяснять не только рост злокачественных новообразований с увеличением возраста, но и более агрессивное течение и неблагоприятный прогноз онкологических заболеваний, в том числе и РМЖ, у пациентов старшей возрастной группы [24].…”

Section: новости в лечении раннего рмж: особые клинические ситуацииunclassified

Following in the footsteps of SABCS 2022: top 16 early breast cancer studies that could change our clinical practice: A review

Kolyadina

2023

J. Mod. Onco.

View full text Add to dashboard Cite

A review of the studies presented at the SABCS 2022 conference on the treatment of breast cancer (BC) has been carried out; 16 of the most exciting and significant works reported at oral or poster sessions have been identified. Data from large randomized and population-based studies were presented, including TAM-01 (the role of adjuvant therapy with 5 mg tamoxifen for in situ cancer), six studies on the surgical treatment of early breast cancer, including a meta-analysis to assess the effect of surgery extent on overall survival, a comparison of the results of targeted lymph node dissection and biopsy of sentinel lymph nodes in patients after neoadjuvant systemic therapy, an analysis of the local relapse rate after breast-conserving surgery in patients with multicentric breast cancer, as well as the effect of carrier status of pathogenic variants of mutations in the ATM, BRCA1, BRCA2, CHEK2 and PALB2 genes on the occurrence of cancer of the contralateral breast. Among the systemic therapy studies, the 10-years results of APT trial, Peony trial were presented, as well as the results of the TMC analysis on the various roles of carboplatin addition in neoadjuvant chemotherapy regimens in patients younger and older than 50 years with triple-negative breast cancer, randomized clinical studies on the escalation of adjuvant endocrine therapy in high relapse risk groups (MonarchE and SWOG S1207), as well as new data on cognitive dysfunction after chemotherapy in patients in the RxPONDER trial. Also noteworthy are the reviews of treatment in special clinical situations: the first results of the POSITIVE trial (an assessment of the oncological and obstetric outcomes of interruption of adjuvant endocrine therapy for conception), an analysis of the mortality of males with breast cancer over the past 20 years, as well as an analysis of the methylmalonic acid effect on senile weakness in patients with early breast cancer.

show abstract

Mass Spectrometry Analysis of Urinary Methylmalonic Acid to Screen for Metabolic Vitamin B ₁₂ Deficiency in Older Adults

Cited by 9 publications

References 44 publications

Exploiting residual cocoa biomass to extract advanced materials as building blocks for manufacturing nanoparticles aimed at alleviating formation-induced oxidative stress on human dermal fibroblasts

Exploiting residual cocoa biomass to extract advanced materials as building blocks for manufacturing nanoparticles aimed at alleviating formation-induced oxidative stress on human dermal fibroblasts

Human Milk Composition and Nutritional Status of Omnivore Human Milk Donors Compared with Vegetarian/Vegan Lactating Mothers

Following in the footsteps of SABCS 2022: top 16 early breast cancer studies that could change our clinical practice: A review

Contact Info

Product

Resources

About

Mass Spectrometry Analysis of Urinary Methylmalonic Acid to Screen for Metabolic Vitamin B 12 Deficiency in Older Adults

Cited by 9 publications

References 44 publications

Exploiting residual cocoa biomass to extract advanced materials as building blocks for manufacturing nanoparticles aimed at alleviating formation-induced oxidative stress on human dermal fibroblasts

Exploiting residual cocoa biomass to extract advanced materials as building blocks for manufacturing nanoparticles aimed at alleviating formation-induced oxidative stress on human dermal fibroblasts

Human Milk Composition and Nutritional Status of Omnivore Human Milk Donors Compared with Vegetarian/Vegan Lactating Mothers

Following in the footsteps of SABCS 2022: top 16 early breast cancer studies that could change our clinical practice: A review

Contact Info

Product

Resources

About

Mass Spectrometry Analysis of Urinary Methylmalonic Acid to Screen for Metabolic Vitamin B ₁₂ Deficiency in Older Adults