Mass Spectrometric Identification of Antimicrobial Peptides from Medicinal Seeds

Moyer, Tessa B.; Brechbill, Amanda M.; Hicks, Leslie M.

doi:10.3390/molecules26237304

Cited by 6 publications

(5 citation statements)

References 65 publications

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“…Other proteomic studies identified novel proteins/peptides of medicinal plant origin with pharmacological interests (Figure 3, grey part) (Moyer et al, 2021b). For instance, seven novel peptides belonging to three antimicrobial peptide classes, including lipid transfer proteins, snakins and a defensin, were identified by MSbased peptidomics analysis from the aerial tissues of edible amaranth (Amaranthus tricolor) plants (Moyer et al, 2021a).…”

Section: Figurementioning

confidence: 99%

Advances in Discoveries of Plant Phytochemicals

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Figurementioning

confidence: 99%

Advances in Discoveries of Plant Phytochemicals

2024

Frontiers Research Topics

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“…Regarding selectivity and recovery, affinity chromatography methods are the most effective downstream processing techniques at the moment (Vollet Marson et al, 2020). Further identification of the peptide can be achieved using mass spectrometry (Moyer et al, 2021) and combination methods (tandem mass spectrometry in combination with LC-MS) (Zhang et al, 2022).…”

Section: Identification and Analyses Of Ppdpmentioning

confidence: 99%

Plant protein-derived peptides: frontiers in sustainable food system and applications

Nirmal,

Khanashyam,

Shah

et al. 2024

Front. Sustain. Food Syst.

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Plant proteins have been considered a potential source of bio-functional peptides, which can be beneficial for human health. The potent antioxidant properties of plant-based peptides protect against oxidative damage and associated diseases. Despite a significant number of studies on the preparation and biological functions of plant-based peptides, only a limited number of peptides are commercially utilized. The systematic studies of the extraction, optimization, isolation, pharmacokinetics, stability, and safety aspects of plant protein-derived peptides (PPDP) are in progress. Also, the molecular mechanism of action and health benefits of bioactive PPDP is still lacking. Hence, this review provides a comprehensive discussion of various plant protein sources to end-product applications of PPDP. In this context, different plant sources explored for functional and bioactive PPDP have been presented. The green biotechnological techniques such as fermentation and enzymatic hydrolysis for extraction of PPDP have been described. The functional and biological properties of PPDP have been revisited. The most important part of the application which includes the stability and bioavailability of PPDP has been discussed. Additionally, the health impact of PPDP administration has been summarized. Lastly, future perspectives and concluding remarks have been documented.

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“…Other proteomic studies identified novel proteins/peptides of medicinal plant origin with pharmacological interests ( Figure 3 , grey part) ( Moyer et al., 2021b ). For instance, seven novel peptides belonging to three antimicrobial peptide classes, including lipid transfer proteins, snakins and a defensin, were identified by MS-based peptidomics analysis from the aerial tissues of edible amaranth ( Amaranthus tricolor ) plants ( Moyer et al., 2021a ).…”

Section: Proteomic Dissection Of Medicinal Plants In Different Manner...mentioning

confidence: 99%

Integration of high-throughput omics technologies in medicinal plant research: The new era of natural drug discovery

Zhang

Zhou²,

Meng³

et al. 2023

Front. Plant Sci.

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Medicinal plants are natural sources to unravel novel bioactive compounds to satisfy human pharmacological potentials. The world’s demand for herbal medicines is increasing year by year; however, large-scale production of medicinal plants and their derivatives is still limited. The rapid development of modern technology has stimulated multi-omics research in medicinal plants, leading to a series of breakthroughs on key genes, metabolites, enzymes involved in biosynthesis and regulation of active compounds. Here, we summarize the latest research progress on the molecular intricacy of medicinal plants, including the comparison of genomics to demonstrate variation and evolution among species, the application of transcriptomics, proteomics and metabolomics to explore dynamic changes of molecular compounds, and the utilization of potential resources for natural drug discovery. These multi-omics research provide the theoretical basis for environmental adaptation of medicinal plants and allow us to understand the chemical diversity and composition of bioactive compounds. Many medicinal herbs’ phytochemical constituents and their potential health benefits are not fully explored. Given their large diversity and global distribution as well as the impacts of growth duration and environmental factors on bioactive phytochemicals in medicinal plants, it is crucial to emphasize the research needs of using multi-omics technologies to address basic and applied problems in medicinal plants to aid in developing new and improved medicinal plant resources and discovering novel medicinal ingredients.

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Mass Spectrometric Identification of Antimicrobial Peptides from Medicinal Seeds

Cited by 6 publications

References 65 publications

Advances in Discoveries of Plant Phytochemicals

Advances in Discoveries of Plant Phytochemicals

Plant protein-derived peptides: frontiers in sustainable food system and applications

Integration of high-throughput omics technologies in medicinal plant research: The new era of natural drug discovery

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