2006
DOI: 10.1002/rcm.2587
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Mass spectrometric identification and characterization of a new long‐term metabolite of metandienone in human urine

Abstract: Anabolic-androgenic steroids are some of the most frequently detected drugs in amateur and professional sports. Doping control laboratories have developed numerous assays enabling the determination of administered drugs and/or their metabolic products that allow retrospectives with respect to pharmacokinetics and excretion profiles of steroids and their metabolites. A new metabolite generated from metandienone has been identified as 18-nor-17beta-hydroxymethyl,17alpha-methyl-androst-1,4,13-trien-3-one in excre… Show more

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Cited by 119 publications
(156 citation statements)
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References 22 publications
(50 reference statements)
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“…More recently, LC-MS/MS has proven to be a powerful tool in the detection and elucidation of previously unreported steroid metabolites (Schänzer et al, 2006;Pozo et al, 2008b,d). New metabolites of some anabolic steroids such as metandienone (Schänzer et al, 2006) or fluoxymesterone (Pozo et al, 2008d) were identified by LC-MS/MS.…”
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confidence: 99%
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“…More recently, LC-MS/MS has proven to be a powerful tool in the detection and elucidation of previously unreported steroid metabolites (Schänzer et al, 2006;Pozo et al, 2008b,d). New metabolites of some anabolic steroids such as metandienone (Schänzer et al, 2006) or fluoxymesterone (Pozo et al, 2008d) were identified by LC-MS/MS.…”
mentioning
confidence: 99%
“…New metabolites of some anabolic steroids such as metandienone (Schänzer et al, 2006) or fluoxymesterone (Pozo et al, 2008d) were identified by LC-MS/MS. Triple quadrupole instruments seem to be ideal tools for this purpose because of the variety of scan modes that can be applied, including precursor ion scan (Thevis et al, 2005a;Schänzer et al, 2006;Pozo et al, 2008a,b) and neutral loss (Pozo et al, 2008b,d). Analyzers with accurate mass capabilities such as TOF or Orbitrap have also been incorporated in doping control analysis (Thevis et al, 2005b;Georgakopoulos et al, 2007;Kolmonen et al, 2007).…”
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confidence: 99%
“…Also from a practical point of view, a method being fit for purpose cannot be taken for granted. It follows that studies like the one reported in [3] can only lead to unsubstantiated claims with respect to specificity. This is a serious problem in practice because any lack of specificity remains unnoticed, unless specifically addressed.…”
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confidence: 92%
“…A case in point is the recently improved test for metandienone [3]. The authors seem to assume that specificity comes for free with the mass spectrometric identification and characterization of the substance of interest.…”
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confidence: 99%
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