Mass spectrometric analysis of exhaled breath: Recent advances and future perspectives

Slug-Flow Microextraction Mass Spectrometry for Enhanced Detection of Analytes in Human Tear Fluids using Noninvasive Microsampling and Nanoelectrospray Ionization via a Capillary

“…Mass spectrometry (MS) is a powerful analytical tool for identification and quantification of complex biological and clinical samples. − Conventionally, MS analysis of tear samples often requires large-volume sample consumption and extensive sample preparation such as extraction, enrichment, and chromatographic separation, which are labor-intensive and time-consuming processes. ,, These limitations can create serious obstacles to use tear fluid as clinical sources for disease diagnosis and tear research. Recently, significant progress has been made in the new development of sample preparation and MS methods.…”