Mass spectra of methyl esters of brominated fatty acids and their presence in soft drinks and cocktail syrups

Bendig, Paul; Maier, Lisa; Lehnert, Katja; Knapp, Holger; Vetter, Walter

doi:10.1002/rcm.6543

Cited by 7 publications

(2 citation statements)

References 21 publications

(46 reference statements)

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“…Though not reported to cause CVDs, these contribute to the total lipophilic load in body serum and can facilitate the absorption of toxic hydrophiles. These chemicals include: mycotoxins produced by molds and found in wet environments and in contaminated foods (Reddy & Bhoola, 2010; Peraica et al , 1999; Brasel et al , 2004; Brewer et al , 2013); antioxidants put into foods and cosmetics for preservation purposes, including BHA and BHT, (Conning and Phillips, 1986; Verhangen et al , 1989); triclosan, an antibacterial compound widely used in tooth paste, cleaners and other consumer products (Sandborgh-Englund et al , 2006); brominated vegetable oil, used to stabilize citrus-flavored soft drinks (Bernal et al , 1986; Bendig et al , 2013); lipophilic pharmaceuticals, examples of which are statins, taken regularly (Culver et al , 2012; Zeliger, 2012), and pharmaceuticals contained in contaminated drinking water (Donn, 2008). …”

Section: Resultsmentioning

confidence: 99%

Lipophilic chemical exposure as a cause of cardiovascular disease

Zeliger¹

2013

Interdisciplinary Toxicology

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Environmental chemical exposure has been linked to numerous diseases in humans. These diseases include cancers; neurological and neurodegenerative diseases; metabolic disorders including type 2 diabetes, metabolic syndrome and obesity; reproductive and developmental disorders; and endocrine disorders. Many studies have associated the link between exposures to environmental chemicals and cardiovascular disease (CVD). These chemicals include persistent organic pollutants (POPs); the plastic exudates bisphenol A and phthalates; low molecular weight hydrocarbons (LMWHCs); and poly nuclear aromatic hydrocarbons (PAHs). Here it is reported that though the chemicals reported on differ widely in chemical properties and known points of attack in humans, a common link exists between them. All are lipophilic species that are found in serum. Environmentally induced CVD is related to total lipophilic chemical load in the blood. Lipophiles serve to promote the absorption of otherwise not absorbed toxic hydrophilic species that promote CVD.

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Section: Resultsmentioning

confidence: 99%

Lipophilic chemical exposure as a cause of cardiovascular disease

Zeliger¹

2013

Interdisciplinary Toxicology

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“…These include gas chromatography with flame ionization detection (GC-FID) (Chadha, Lawrence, & Conacher, 1986; Conacher, Chadha, & Sahasrabudhe, 1969; Lawrence, Chadha, & Conacher, 1983), GC coupled with mass spectrometry (GC–MS) (Bendig, Maier, Lehnert, Knapp, & Vetter, 2013; Bendig, Maier, & Vetter, 2012), liquid chromatography with ultraviolet detection (LC-UV) (Lawrence, Chadha, & Conacher, 1987), and bromide ion detection approaches (Turner, 1972; Yousef et al, 2012). All these methods are indirect methods for the identification and quantification of BVO and involve the chemical degradation of the triglyceride structures to derivatized brominated fatty acids or to bromide ions.…”

Section: Introductionmentioning

confidence: 99%

Simple and rapid quantification of brominated vegetable oil in commercial soft drinks by LC–MS

Chitranshi

Costa

2016

Food Chemistry

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We report here a simple and rapid method for the quantification of brominated vegetable oil (BVO) in soft drinks based upon liquid chromatography–electrospray ionization mass spectrometry. Unlike previously reported methods, this novel method does not require hydrolysis, extraction or derivatization steps, but rather a simple “dilute and shoot” sample preparation. The quantification is conducted by mass spectrometry in selected ion recording mode and a single point standard addition procedure. The method was validated in the range of 5–25 μg/mL BVO, encompassing the legal limit of 15 μg/mL established by the US FDA for fruit-flavored beverages in the US market. The method was characterized by excellent intra- and inter-assay accuracy (97.3–103.4%) and very low imprecision [0.5–3.6% (RSD)]. The direct nature of the quantification, simplicity, and excellent statistical performance of this methodology constitute clear advantages in relation to previously published methods for the analysis of BVO in soft drinks.

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Chemical Ionization

Gross¹

2017

Mass Spectrometry

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Mass spectra of methyl esters of brominated fatty acids and their presence in soft drinks and cocktail syrups

Abstract: BVO was determined for the first time in syrup samples. Attention should be paid to the problem of BVO occurring unlabeled in soft drinks and cocktail syrups imported from North America.

Cited by 7 publications

References 21 publications

Lipophilic chemical exposure as a cause of cardiovascular disease

Lipophilic chemical exposure as a cause of cardiovascular disease

Simple and rapid quantification of brominated vegetable oil in commercial soft drinks by LC–MS

Chemical Ionization

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