By the use of site-specific and stereospecific deuterium labelling, it has been possible to show that loss of the elements of water from all possible bicycIo[3.3.l]nonanols (I to V) in the mass spectrometer, takes place in a substantially stereospecific manner. The position of abstraction of the hydrogen atom by the hydroxyl group can be related to the proximity effects that are present in the ground state conformers, while the [M]+/[M -H,O]+ ratio appears to depend on the minimum H---OH intramolecular distance in the more stable conformations.