Mass screening and eradication of Helicobacter pylori as the policy recommendations for gastric cancer prevention

Chiang, Tsung-Hsien; Cheng, Hsiu–Chi; Chuang, Shu‐Lin; Chen, Yi-Ru; Hsu, Yung‐Ho; Hsu, Tsui-Hsia; Lin, Li‐Hung; Lin, Yu-Wen; Chu, Chia–Hsiang; Wu, Ming–Shiang; Lee, Yi–Chia

doi:10.1016/j.jfma.2022.08.012

Cited by 7 publications

(5 citation statements)

References 85 publications

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“…However, successful eradication of Hp infection significantly improves the cure rate of Hp-related gastric inflammation. [ 14 ] Besides Hp infection, the development of chronic atrophic gastritis is influenced by various factors, including patients’ dietary habits, nutritional intake, and genetic factors. [ 15 ] Therefore, investigating the prevalence of Hp infection in patients with chronic atrophic gastritis and its correlation with lifestyle habits and dietary factors holds significant importance for the prevention and management of chronic atrophic gastritis and associated conditions.…”

Section: Discussionmentioning

confidence: 99%

Study of Helicobacter pylori infection in patients with chronic atrophic gastritis and its relationship with lifestyle habits and dietary nutrient intake: A retrospective analysis

Li,

Zhu,

Ding

et al. 2024

Medicine

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To explore Helicobacter pylori (Hp) infection status and its relationship with lifestyle habits and dietary factors in patients with chronic atrophic gastritis. Six hundred thirty-eight patients with chronic atrophic gastritis, who were admitted to our hospital from March 2021 to April 2023, were selected for the study. All patients underwent the 13C urea breath test. The relationship between the detection rate of Hp infection and the clinical characteristics, lifestyle habits, and dietary factors of the patients was analyzed. Among the 638 patients with chronic atrophic gastritis, 531 patients were tested positive for Hp infection, the positive rate for Hp infection was approximately 83.23%. Analyzing the clinical characteristics of the patients, it was found that age, family history of gastric cancer, degree of chronic inflammation, degree of glandular atrophy, presence of low-grade dysplasia, and intestinal metaplasia all have an impact on the positive detection rate of patients (P < .05). Analyzing the patients’ lifestyle habits, it was found that BMI, smoking history, alcohol consumption, preference for spicy food, dining location, consumption of pickled foods, frequent consumption of grilled/barbecued foods, preference for strong tea, consumption of sweets, and work-related stress had an impact on the positive rate of Hp infection in patients (P < .05). The discovery showed that the levels of total protein, albumin, hemoglobin, cholesterol, and the intake of livestock and poultry meat, seafood, dairy products, vegetables, fruits, and fats have an impact on the positivity rate of Hp infection in patients (P < .05). A multiple logistic regression analysis was performed, and it was found that patients’ age, family history of gastric cancer, degree of chronic inflammation, degree of glandular atrophy, presence of low-grade dysplasia, presence of wasting or obesity, history of alcohol consumption, preference for spicy food, dining location, frequent consumption of strong tea, high work pressure, high intake of fish and seafood, low intake of dairy products, low intake of vegetables, low intake of fruits, and low intake of fats all had an impact on the occurrence of Hp infection in patients (P < .05). There is a certain correlation between patients’ lifestyle habits, dietary factors, and clinical characteristics with the occurrence of Hp infection. These factors can assist in the prevention of Hp infection.

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Section: Discussionmentioning

confidence: 99%

Study of Helicobacter pylori infection in patients with chronic atrophic gastritis and its relationship with lifestyle habits and dietary nutrient intake: A retrospective analysis

Li,

Zhu,

Ding

et al. 2024

Medicine

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“…Second, similar to those designed for the screening of other prevalent cancers,42 our quality indicators are readily generalisable for mass screening and eradication for H. pylori infection; however, the minimal requirement levels may need to be adjusted in a compliance-resistant population. Finally, the long-term goal of this programme is to reduce the rate of newly occurring gastric cancer,43 which requires continuous observation of the trend in gastric cancer incidence and quantification of the magnitude of any declines, as adopted in our previous study with the number needed to treat of about 170 to prevent one gastric cancer 9 11…”

Section: Discussionmentioning

confidence: 99%

“…This transition overcomes the previous need to develop an intensive scheme for endoscopic screening and rely on a trained endoscopist workforce, while expanding the ability to arrest the progression of carcinogenesis. [8][9][10] However, despite the unequivocal benefit from H. pylori eradication supported by randomised trials, cohort studies and costeffectiveness analyses, 9 the population-wide application of this approach, beyond the scope of individual treatment, is rarely realised. 11 This gap partly results from the fact that the number of H. pylori-infected individuals tends to be large, without a sustainable goal with a staggered increase in the coverage rate; the result may be an unaffordable burden in the subsequent management of those who test positive.…”

Section: Helicobacter Pylorimentioning

confidence: 99%

“…Elucidating the natural course of gastric cancer and the causal role of H. pylori infection has prompted a paradigm shift, in which the emphasis traditionally placed on endoscopic early detection has shifted to mass screening and eradication of H. pylori . This transition overcomes the previous need to develop an intensive scheme for endoscopic screening and rely on a trained endoscopist workforce, while expanding the ability to arrest the progression of carcinogenesis 8–10…”

Section: Introductionmentioning

confidence: 99%

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EradicatingHelicobacter pylorivia¹³C-urea breath screening to prevent gastric cancer in indigenous communities: a population-based study and development of a family index-case method

Lei

Lee

Chuang

et al. 2023

Gut

Self Cite

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ObjectiveScreening and eradication ofHelicobacter pylorihelp reduce disparities in the incidence of gastric cancer. We aimed to evaluate its acceptability and feasibility in the indigenous communities and develop a family index-case method to roll out this programme.DesignWe enrolled residents aged 20–60 years from Taiwanese indigenous communities to receive a course of test, treat, retest and re-treat initial treatment failures with the13C-urea breath tests and four-drug antibiotic treatments. We also invited the family members of a participant (constituting an index case) to join the programme and evaluated whether the infection rate would be higher in the positive index cases.ResultsBetween 24 September 2018 and 31 December 2021, 15 057 participants (8852 indigenous and 6205 non-indigenous) were enrolled, with a participation rate of 80.0% (15 057 of 18 821 invitees). The positivity rate was 44.1% (95% CI 43.3% to 44.9%). In the proof-of-concept study with 72 indigenous families (258 participants), family members of a positive index case had 1.98 times (95% CI 1.03 to 3.80) higher prevalence ofH. pylorithan those of a negative index case. The results were replicated in the mass screening setting (1.95 times, 95% CI 1.61 to 2.36) when 1115 indigenous and 555 non-indigenous families were included (4157 participants). Of the 6643 testing positive, 5493 (82.6%) received treatment. According to intention-to-treat and per-protocol analyses, the eradication rates were 91.7% (89.1% to 94.3%) and 92.1% (89.2% to 95.0%), respectively, after one to two courses of treatment. The rate of adverse effects leading to treatment discontinuation was low at 1.2% (0.9% to 1.5%).ConclusionA high participation rate, a high eradication rate ofH. pyloriand an efficient rollout method indicate that a primary prevention strategy is acceptable and feasible in indigenous communities.Trial registration numberNCT03900910.

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“…Helicobacter pylori (Hp) is the bacterium implicated in the etiology of a diverse range of gastrointestinal diseases, such as gastritis, gastric ulcers, MALT lymphoma and, in conjunction with other factors, even gastric cancer [16][17][18][19][20]. Several works have been published concerning the anti-Hp properties shown by aqueous garlic extracts [13,[21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Garlic Extracts: Effect of pH on Inhibition of Helicobacter pylori

García

García-Vargas

Fernández

et al. 2023

Life

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The present work studies the influence of pH on the stability of thiosulfinates, compounds responsible for the bacteriostatic properties shown by ethanolic and acetonic garlic extracts (EGE and AGE) against the in vitro growth of Helicobacter pylori (Hp), a bacterium which is implicated in the etiology of diverse gastrointestinal diseases. The influence of pH and time on the stability of thiosulfinates and the microbiological activities of EGE and AGE has been evaluated at human body temperature (37 °C) and in a pH range of 0.9–4.7. A marked decrease in thiosulfinate concentration was observed in a relatively short time at pH values below 2.0. However, at pH values over 2.0, the samples maintained 70% of thiosulfinate concentration for 12 h. The inhibition halo diameters showed a maximum value at pH 2.50, with an inhibition halo of 28.94 ± 0.61 mm. The reduction in the activity at pH values below 2.0 was particularly remarkable. These results suggest that, for medical application, the pH of the selected extracts must only be maintained above 2 to maintain a high level of antibacterial activity. This fact would overcome the need for proton pump inhibitors and/or antibiotics during the treatment of Hp infections in human patients.

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Mass screening and eradication of Helicobacter pylori as the policy recommendations for gastric cancer prevention

Cited by 7 publications

References 85 publications

Study of Helicobacter pylori infection in patients with chronic atrophic gastritis and its relationship with lifestyle habits and dietary nutrient intake: A retrospective analysis

Study of Helicobacter pylori infection in patients with chronic atrophic gastritis and its relationship with lifestyle habits and dietary nutrient intake: A retrospective analysis

EradicatingHelicobacter pylorivia¹³C-urea breath screening to prevent gastric cancer in indigenous communities: a population-based study and development of a family index-case method

Garlic Extracts: Effect of pH on Inhibition of Helicobacter pylori

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Mass screening and eradication of Helicobacter pylori as the policy recommendations for gastric cancer prevention

Cited by 7 publications

References 85 publications

Study of Helicobacter pylori infection in patients with chronic atrophic gastritis and its relationship with lifestyle habits and dietary nutrient intake: A retrospective analysis

Study of Helicobacter pylori infection in patients with chronic atrophic gastritis and its relationship with lifestyle habits and dietary nutrient intake: A retrospective analysis

EradicatingHelicobacter pylorivia13C-urea breath screening to prevent gastric cancer in indigenous communities: a population-based study and development of a family index-case method

Garlic Extracts: Effect of pH on Inhibition of Helicobacter pylori

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EradicatingHelicobacter pylorivia¹³C-urea breath screening to prevent gastric cancer in indigenous communities: a population-based study and development of a family index-case method