1975
DOI: 10.1016/s0021-9673(00)99981-3
|View full text |Cite
|
Sign up to set email alerts
|

Mass fragmentography of 5-hydroxytryptophol and 5-methoxytryptophol in human cerebrospinal fluid

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
9
0

Year Published

1978
1978
2004
2004

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 24 publications
(9 citation statements)
references
References 14 publications
0
9
0
Order By: Relevance
“…6-OHDA can be formed from dopamine by nonenzymatic hydroxylation in the presence of Fe 2+ and H 2 O 2 (19). Endogenous 6-OHDA was detected in the brain and urine samples of patients suffering from PD (20)(21)(22), suggesting that this compound is involved in the pathogenesis of PD. The cellular and molecular mechanisms by which 6-OHDA induces neuronal loss, however, are not clear.…”
mentioning
confidence: 99%
“…6-OHDA can be formed from dopamine by nonenzymatic hydroxylation in the presence of Fe 2+ and H 2 O 2 (19). Endogenous 6-OHDA was detected in the brain and urine samples of patients suffering from PD (20)(21)(22), suggesting that this compound is involved in the pathogenesis of PD. The cellular and molecular mechanisms by which 6-OHDA induces neuronal loss, however, are not clear.…”
mentioning
confidence: 99%
“…The serotonin metabolite 5-hydroxytryptophol (5-HTOL) occurs in human CSF (Curtius et al, 1975;Takahashi et al, 1978), in rat tissues and fluids (Cheifetz and Warsh, 1980), and in mouse brain (Diggory et al, 1979). Also, CSF 5-HTOL in humans increases during ethanol intoxication and disulfiram therapy, so that alcoholics have higher levels than healthy volunteers, even after abstinence from ethanol for several weeks (Beck et al, 1980a,h;1982).…”
mentioning
confidence: 99%
“…In addition, synergistic effects of tryptophan and ethanol on sleep parameters have been reported in rats (Hill and Reyes, 1978). The structural similarity of tryptamine and tryptophol, together with their roles in sleep induction and the demonstration of endogenously formed 5-hydroxytryptophol in human cerebrospinal fluid (Curtius et al, 1975;Takahashi et al, 1978) and mouse brain (Diggory et al, 1979) seem to indicate a functional role as an endogenous hypnotic (Taborsky, 1971 ;Feldstein and Kucharski, 1971;Feldstein, 1973;Wilson et al, 1978).…”
Section: Discussionmentioning
confidence: 94%