Mass and fiber cross-sectional area of soleus muscle grafts following training

Clark, K. P.; Morales, Pedro; White, Timothy P.

doi:10.1249/00005768-198908000-00015

Cited by 3 publications

(9 citation statements)

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“…Therefore running for 9 or 25 days did not accelerate or modify the growth of venomtreated soleus. However, contrary to regenerating extensor digitorum longus muscle (EDL, Bigard et al 1996a), regenerating soleus can adapt to endurance exercise by increasing its mass (Clark et al 1989;White et al 1984; the present study). Ablation of the synergistic muscle, which is not a natural model of increased mechanical load, also causes hypertrophy of the regenerating (graft) soleus (Esser and White 1995).…”

Section: Muscle Growthcontrasting

confidence: 56%

“…At 25 days the increase in the mass of venom-treated soleus does not appear to be the result of a greater level of connective, or ®brotic, tissues (absolute levels of MHC-1 and protein concentration were not aected by exercise). It is known that exercised regenerating (graft) soleus ®bres increase their cross-sectional area (Clark et al 1989). Since the maximum force (MF) that a muscle can generate is related to its mass and cross-sectional area, it is possible that exercised regenerating soleus could produce a greater MF compared to sedentary regenerating soleus.…”

Section: Muscle Growthmentioning

confidence: 99%

“…Studies also reported that endurance exercise aects the muscle variables during regeneration (Bigard et al 1996a;Clark et al 1989;Esser and White 1995;White et al 1984). Running on a treadmill enhances the mass and the oxidative metabolism of the regenerating soleus (Clark et al 1989;White et al 1984) and causes a shift from type MHC-2b to type MHC-1 in a regenerating fast-twitch muscle (Bigard et al 1996a). Unfortunately, these latter studies have not evaluated the eect of endurance exercise on MHC phenotype of regenerating soleus.…”

Section: Introductionmentioning

confidence: 99%

“…Muscle mass growth (Esser and White 1995) and accumulation of mature (slow) myosin isoform or MHC-1 were decreased by hypokinesia and hypodynamia applied during regeneration of soleus muscle (Bigard et al 1996b;Esser and White 1995). Studies also reported that endurance exercise aects the muscle variables during regeneration (Bigard et al 1996a;Clark et al 1989;Esser and White 1995;White et al 1984). Running on a treadmill enhances the mass and the oxidative metabolism of the regenerating soleus (Clark et al 1989;White et al 1984) and causes a shift from type MHC-2b to type MHC-1 in a regenerating fast-twitch muscle (Bigard et al 1996a).…”

Section: Introductionmentioning

confidence: 99%

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Effect of increased physical activity on growth and differentiation of regenerating rat soleus muscle

Ferry¹,

Noirez²,

Salah³

et al. 1997

European Journal of Applied Physiology

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Our purpose was to determine the effect of physical exercise on growth and differentiation during regeneration of a slow-twitch muscle. Degeneration/regeneration of the left soleus muscles of Wistar female rats was induced by injection of a snake venom. Muscular differentiation was studied by monitoring the sequential expression of the various myosin heavy chain isoforms (MHCs). Rats were assigned to one of two groups: cage sedentary (n = 14) or exercised (n = 16). The exercise programme began 1-day post-injection and the rats ran 1 h/day on a motorized treadmill. Then, 9 and 25 days after venom treatment, the soleus MHC phenotype as determined by immunohistology, electrophoresis and immunoblotting, was studied. At 25 days the expression of MHCs by regenerating soleus was not changed by the increased level of physical activity (P > 0.05). Exercised and sedentary regenerating muscles contained similar numbers of type-I fibres (100% of total fibres), levels of MHC-1 (85.4 and 89.5% of total MHCs), MHC-2a and M/HC-2x/d and their fibres expressed MHC-1 (100% of total fibres) and MHC-2 (45-50%) in the same way. Moreover, the masses of regenerating and nonregenerating soleus were significantly increased by physical exercise (P < 0.02). At 9 days no effect of muscular exercise was found. In conclusion, endurance exercise did not alter differentiation of regenerating soleus. Moreover regenerating soleus can respond to increased physical activity by enhancing its mass in the same way as mature muscle.

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Section: Muscle Growthcontrasting

confidence: 56%

Section: Muscle Growthmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of increased physical activity on growth and differentiation of regenerating rat soleus muscle

Ferry¹,

Noirez²,

Salah³

et al. 1997

European Journal of Applied Physiology

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“…(20) In particular, the back squat can be used to assess an individual for neuromuscular control, strength, stability, and mobility within the kinetic chain. (1, 4, 10, 31, 39, 42)…”

Section: Introductionmentioning

confidence: 99%

The Back Squat

Myer

Kushner

Brent

et al. 2014

Strength &Amp; Conditioning Journal

155

141

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Fundamental movement competency is essential for participation in physical activity and for mitigating the risk of injury, which are both key elements of health throughout life. The squat movement pattern is arguably one of the most primal and critical fundamental movements necessary to improve sport performance, to reduce injury risk and to support lifelong physical activity. Based on current evidence, this first (1 of 2) report deconstructs the technical performance of the back squat as a foundation training exercise and presents a novel dynamic screening tool that incorporates identification techniques for functional deficits that limit squat performance and injury resilience. The follow-up report will outline targeted corrective methodology for each of the functional deficits presented in the assessment tool.

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Motor Unit Properties of Nerve-Intact Extensor Digitorum Longus Muscle Grafts In Young and Old Rats

Cederna¹,

Asato²,

Gu³

et al. 2001

The Journals of Gerontology Series A: Biological Sciences and M

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Impaired reinnervation has been implicated as the cause of the threefold disparity in the recovery of maximum force (P0) of standard muscle grafts in old compared with young rats. The specific, null hypothesis of this study is that compared with age-matched control extensor digitorum longus (EDL) muscles, nerve-intact EDL muscle grafts in young and old rats show no evidence of an age-related impairment in reinnervation. Nerve-intact grafts were performed in 3-month-old and 23-month-old rats and were evaluated 60 days postoperatively. Compared with age-matched control EDL muscles, nerve-intact grafts in young and old rats showed no difference in muscle mass or motor unit numbers. The mean motor unit P0 for nerve-intact graft muscles in both age groups was significantly lower than that of age-matched control muscles. These data support our hypothesis that if axons are allowed to regenerate in an endoneurial environment, there is no evidence of an age-related impairment in muscle reinnervation.

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Mass and fiber cross-sectional area of soleus muscle grafts following training

Cited by 3 publications

References 0 publications

Effect of increased physical activity on growth and differentiation of regenerating rat soleus muscle

Effect of increased physical activity on growth and differentiation of regenerating rat soleus muscle

The Back Squat

Motor Unit Properties of Nerve-Intact Extensor Digitorum Longus Muscle Grafts In Young and Old Rats

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