Mass and Fat Infiltration of Intercostal Muscles Measured by CT Histogram Analysis and Their Correlations with COPD Severity

Park, Mi Jung; Cho, Jae Min; Jeon, Kyung Nyeo; Bae, Kyung‐Yeol; Kim, Ho Cheol; Choi, Dae Seob; Na, Jae Boem; Choi, Ho Cheol; Choi, Hye Young; Kim, Ji Eun; Shin, Hwa Seon

doi:10.1016/j.acra.2014.02.003

Cited by 31 publications

(31 citation statements)

References 35 publications

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“…In previous studies the area of pectoralis or latissimus dorsi muscles showed correlation with the COPD severity (9,10). In our study the area of pectoralis muscles weren't statistically significant in the correlation with the results of PFT.…”

Section: Discussioncontrasting

confidence: 84%

“…In the present study, CSA and attenuation of respiratory mus- (10,22). In previous studies the area of pectoralis or latissimus dorsi muscles showed correlation with the COPD severity (9,10).…”

Section: Discussionsupporting

confidence: 59%

“…CSA and attenuation of intercostalis showed moderate agreement and severe variation in attenuation measurements due to inaccuracy of manual measurement in thin muscle. A previous study had shown good correlation between measurements of intercostal muscle and COPD severity, using CT histogram; in that study, bilateral twelve intercostals muscles have been evaluated (10). Sum of total areas would be more reliable in the case of intercostals muscles according to the result of our and previous study.…”

Section: Discussionsupporting

confidence: 50%

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Quantitative Computed Tomography Assessment of Respiratory Muscles in Male Patients Diagnosed with Emphysema

Han

Lee

Kang

et al. 2018

J Korean Soc Radiol

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Purpose:The aim of this study was to accurately evaluate the significance and correlation between the clinical severity and the morphologic feature of respiratory muscles in patients with emphysema as noted using computed tomography (CT). Materials and Methods:The cross sectional area (CSA) and attenuation of respiratory muscles in the patients with emphysema (n = 71) were subsequently retrospectively reviewed. The clinical severity for the patients was determined by the value of the actual forced expiratory volume in 1 second/forced vital capacity at the pulmonary function test (PFT). The correlation between the CT measurements with visual assessment of emphysema (VAE), and the PFT values were completed and recorded. The multiple linear regression analysis of each CT measurement on the VAE and PFT values was used to determine the most affective parameters among the recorded and identified CT measurements. Results: The CSA of the pectoralis major (p = 0.002) and subsequently the serratus anterior (p = 0.011) were found to be lower in patients with emphysema than as compared to those in the control group. The CSA and the attenuation of respiratory muscles remained significant for its relation for the VAE and PFT values. As noted, both the VAE and PFT values were mostly contributed by the CSA and attenuation of serratus anterior and attenuation of diaphragm crus among all respiratory muscles. Conclusion: The CT measurement of the patient's respiratory muscles may reflect clinical and visual severity in the patients with emphysema. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Index terms

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Section: Discussioncontrasting

confidence: 84%

Section: Discussionsupporting

confidence: 59%

Section: Discussionsupporting

confidence: 50%

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Quantitative Computed Tomography Assessment of Respiratory Muscles in Male Patients Diagnosed with Emphysema

Han

Lee

Kang

et al. 2018

J Korean Soc Radiol

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“…The first, second, and ninth to twelfth ICMs were excluded because it is difficult to differentiate their boundaries from the adjacent chest wall and diaphragm. 16 These analyses were performed by two radiologists blinded to patients' characteristics. The inter-observer reliability coefficient was high (kappa coefficient 5 0.76).…”

Section: Measurement Of Intercostal Cross-sectional Area With Chest Ctmentioning

confidence: 99%

Clinical importance of cross‐sectional area of intercostal muscles in patients with chronic obstructive pulmonary disease

Lee

Park

et al. 2017

Clinical Respiratory J

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Background and Aims: Patients with COPD exhibit persistent dys-pnea in daily activities and irreversible airflow obstruction. These will finally lead to inability to carry on daily activities and markedly decrease their quality of life. Endurance training was now considered as therapy modality to alleviate several symptoms experienced by COPD patients. The aim of this study is to identify the impact of lower-limb endurance training on dys-pnea symptom and pulmonary function test results in COPD patients. Methods: We performed experimental study in July 2017 on 20 stable COPD patients divided both in group C and D according to GOLD 2017 criteria. Patients were given individualized dose of stationary cycling twice a week for one month in which every session lasted 5-20 minutes gradually. Before and after rehabilitation program, pulmonary function tests were measured by spirometry to obtain percent predicted of FEV1, FVC, PEFR and FEF 25-75, while dyspnea scale was measured by mMRC index. Statistical analysis was performed by Wilcoxon and T-dependent test. Results: Baseline value of FVC (49.6AE21.6%) increased significantly to 59.65AE16.53% after one month of endurance training program (p=0.01). Surprisingly, there was also significant increase of FEV1 value from 46.9AE21.7 to 52.9AE20.7% (p<0.005). The increase of FVC and FEV1 in group C was slightly higher than in group D although not statistically significant (p=0.29; p=0.25 respectively). However, no difference was observed in PEFR and FEF25-75 value (p>0.05). Patients' dyspnea index also showed significant improvement (p<0.001) from mMRC median scale 2 (range 1-3) to 1 (range 0-2) in both group C and D. There was no exacerbation found during rehabilitation program. Conclusions: Twice a week lower-limb endurance training for one-month improved dyspnea scale and pulmonary function test results of COPD patients safely and effectively Background and Aims: Limb muscle wasting is one of main sys-temic manifestation of chronic obstructive pulmonary disease (COPD). However, the change of respiratory muscle is unclear. This study assessed the cross-sectional area (CSA) of the intercostal muscles (ICMs) in patients with COPD, using chest computed tomography (CT) and determined its association with the clinical characteristics of COPD. Methods: They retrospectively reviewed 60 patients with stable COPD and compared them with 30 controls. CSA (mm(2)) of the ICM on chest CT was measured at the midline level of the lateral arch of the bilateral first rib with a 3-mm slice thickness by using CT histogram software. The association with the clinical characteristics of COPD and with the control groups was assessed. Results: CSA of the ICM and the CSA/body mass index (BMI) were lower in the COPD group than in the control group. Patients with Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 4 had a significantly lower CSA of the ICM than patients with stage 1, 2, and 3. CSA of the ICM was positively associated with FEV1 , %FEV1 predicted, FEV1 /FVC ratio, and B...

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“…CT assessment of lumbar skeletal mass is a validated method to assess sarcopenia in (lung) cancer, which in turn is associated with increased mortality and risk for chemotherapy-induced toxicity [30]. Several studies in 2014 also evaluated the potential of chest CT-derived estimates of body composition in patients with COPD, including CT-assessed bone attenuation [31], muscle and fat infiltration of intercostal muscles [32] and CT measurements of the pectoralis muscle area [33]. In all three cross-sectional studies these estimates were related to measures of clinical outcome but, surprisingly, were not validated against references methods.…”

Section: New Developments In Body Composition Assessment To Charactermentioning

confidence: 99%

Nutritional advances in patients with respiratory diseases

Schols

2015

Eur Respir Rev

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Nutritional issues are increasingly recognised in the course of respiratory diseases, from primary prevention to advanced disease care. During the 2014 ERS International Congress in Munich, Germany, the topic was addressed in a Clinical Year in Review session. This review highlights new insights in generic and disease-specific nutritional issues from recently published peer-reviewed articles. The clinical relevance of obesity was highlighted in primary and secondary prevention across all respiratory diseases. Radiographic imaging was explored for characterisation of metabolic phenotypes as an integrated part of diagnostic work-up. Muscle regenerative defects and the autophagy-lysosome pathway were identified as new leads for combatting muscle wasting. @ERSpublications Nutritional issues need to be considered in respiratory disease, from primary prevention to advanced disease care http://ow.ly/GVI5D

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Mass and Fat Infiltration of Intercostal Muscles Measured by CT Histogram Analysis and Their Correlations with COPD Severity

Cited by 31 publications

References 35 publications

Quantitative Computed Tomography Assessment of Respiratory Muscles in Male Patients Diagnosed with Emphysema

Quantitative Computed Tomography Assessment of Respiratory Muscles in Male Patients Diagnosed with Emphysema

Clinical importance of cross‐sectional area of intercostal muscles in patients with chronic obstructive pulmonary disease

Nutritional advances in patients with respiratory diseases

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