MASP‐3 aggregation and its blood to cerebrospinal fluid diffusion.

Abstract

IntroducctionMASP‐3 functions are not clarified totally, in spite of that it is a regulatory protein from the lectin pathway. It can be found as complexes and its molecular weight is around 105 KDa.Materials and methodsMASP‐3 and albumin from serum and cerebrospinal fluid were quantified by immune‐enzimatic test in a 60 control group without inflammatory process. Q (cerebrospinal fluid/serum) ratio was performed. QMASP‐3 was order and its relative frequency was calculated.ResultsFrom the different inflexion points of the relative frequency was found five different molecular orders and it's identified with a same number of aggregation forms. Blood‐cerebrospinal fluid allows the protein diffusion according to it molecular size and its relationship with their molecular flow.This five aggregation forms was associated with the molecular flow of this structures throughout blood‐cerebrospinal barrier. It takes into account that the structure that diffuses more rapidly should be the 105 KDa native structure y it is possible to associate this aggregation with native multiple structures and its molecular flow.