Masked hypodiploidy in anaplastic meningiomas by duplication of the original clone found in atypical meningiomas: Illustration of the evolution of genetic alterations

Ely, Erin E.; Guzmán, Miguel A.; Calvey, Laura S.; Batanian, Jacqueline R.

doi:10.1111/neup.12112

Cited by 1 publication

(1 citation statement)

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“…Since 22q was established the most frequent aberration in MGs, authors focused on cytogenetic profiling of MG tumorigenesis or progression. A broad array of the loci was postulated, including 1p, 3q, 6q, 9p, 9q, 10p, 10q, 14q, 14p, 18p, 18q and 22q [10,20,23,24]. Moreover, single nucleotide polymorphism (SNP) demonstrated loss of heterozygosity (LOH) on several loci within one cytoband in MGs [21].…”

Section: Introductionmentioning

confidence: 99%

The correlation of clinical and chromosomal alterations of benign meningiomas and their recurrences

Och

Szmuda

Kulbacki

et al. 2016

Neurologia i Neurochirurgia Polska

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Meningiomas (MGs) are the frequent benign intracranial tumors. Their complete removal does not always guarantee relapse-free survival. Recurrence-associated chromosomal anomalies in MGs haves been proposed as prognostic factors in addition to the World Health Organisation (WHO) grading, tumor size and resection rate. The aim of this study was to evaluate the frequency of deletions on chromosomes in sporadic MGs and to correlate them with the clinical findings and tumor behaviour. Along with survival, the tumor recurrence was the main endpoint. Chromosomal loss of heterozygosity (LOH) was studied. 46 benign MGs were subjected to the analysis, complete tumor resection was intended and no early mortalities were observed. Incomplete removal was related to parasagittal location and psammomatous hisptopathology (p<0.01). Chromosomal alterations were present in 82.6% of cases; LOH at 22q (67.4%) and 1p (34.8%) were the most frequent and associated with male sex (p=0.04). Molecular findings were not specific for any of the histopathologic grade. Tumor recurrence (14 of 46) correlated with tumor size (≥35mm), LOH at 1p, 14q, coexistence of LOH at 1p/14q, 10q/14q, 'complex karyotype' status (≥2 LOHs excluding 22q), patient age (younger <35), and Simpson grading of resection rate (≥3 of worse prognosis). The last 3 variables were independent significant prognostic factors in multivariate analysis and of the same importance in recurrence prediction (Receiver Operating Characteristic curves comparison p>0.05). Among the cases of recurrence, tumor progression was observed in 3 of 14. In 2 cases, LOH on 1p and/or coexistence of LOH 1p/14q correlated with anaplastic transformation.

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