Masked hypertension is associated with end organ damage in geriatric age: Geriatric MASked Hypertension and End organ damage (G-MASH-End organ Study)

Eşme, Mert; Asil, Serkan; Yavuz, Bünyamin; Balcı, Cafer; Kılıç, Mustafa; Varan, Hacer Doğan; Doğrul, Rana Tuna; Halil, Meltem; Cankurtaran, Mustafa; Yavuz, Burcu Balam

doi:10.1080/08037051.2019.1675475

Cited by 4 publications

(5 citation statements)

References 22 publications

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“…Masked hypertension is known to cause target organ damage [25–28]. Kidney damage was assessed with proteinuria and reduction in GFR [25–27]. In support of this fact, GFR was significantly lower in those with masked hypertension in our study.…”

Section: Discussionsupporting

confidence: 77%

“…Masked hypertension is known to cause target organ damage [25][26][27][28]. Kidney damage was assessed with proteinuria and reduction in GFR [25][26][27].…”

Section: Discussionmentioning

confidence: 99%

“…However, the fact that creatinine and GFR are within normal limits in masked hypertension does not mean that there is no kidney damage. It is also known that masked hypertension leads to an increase in LVMI [26,28,29]. In the study by Yilmaz et al ., when ABPM was applied to people with unexplained LVH, masked hypertension was found more frequently and left atrium dimensions were larger [30].…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, some studies have found no increase in LWMI in patients with masked hypertension [31,32]. Age may be higher in studies with high LVMI [26]. In a study in which nearly two thousand patients were evaluated, masked hypertension subgroups and normotensive individuals were compared with target organ damage, and no difference was observed between the groups in terms of LWMI [32].…”

Section: Discussionmentioning

confidence: 99%

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Aortic arch calcification: a novel parameter for prediction of masked hypertension

Akbay

Çoner

Akıncı

et al. 2021

Blood Pressure Monitoring

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Background Masked hypertension is directly related to increased cardiovascular morbidity and mortality but remains underdiagnosed in clinical practice. The aim of the study was to search the role of aortic arch calcification (AAC) in the diagnosis of masked hypertension. Methods and results Among the patients who underwent ambulatory blood pressure monitoring (ABPM) in our clinic, those with office blood pressure (OBP) <140/90 mmHg were included in the study population. According to OBP, they were divided into two groups as normal (<130/85 mmHg) and high normal (130–139/85–89 mmHg) OBP groups. Subjects were also investigated for the presence of masked hypertension with ABPM and searched in masked hypertension and control groups. Masked hypertension was defined as in the latest 2017 ACC/AHA Hypertension guideline and was diagnosed as the daytime BP ≥ 135/85 mmHg and nighttime BP ≥ 120/70 mmHg. AAC was evaluated on direct X-ray telecardiography. Diagnosis of masked hypertension was searched depending on the presence of AAC and OBP measurements as well. A total of 216 volunteers were involved in the study [mean age 45.2 ± 12.2 years; female gender 120 (55.5%)]. One hundred ten volunteers (50.9%) had masked hypertension according to the ABPM. AAC was significantly more common in the masked hypertension group (44.5% vs. 26.4%) (P = 0.005). AAC had a positive predictive value of 79% in those with high normal OBP in the diagnosis of masked hypertension, and also AAC had a negative predictive value of 74% in those with normal OBP. Conclusion AAC can be used as a reliable diagnostic tool to exclude and predict masked hypertension during office examination.

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Section: Discussionsupporting

confidence: 77%

“…Masked hypertension is known to cause target organ damage [25][26][27][28]. Kidney damage was assessed with proteinuria and reduction in GFR [25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Aortic arch calcification: a novel parameter for prediction of masked hypertension

Akbay

Çoner

Akıncı

et al. 2021

Blood Pressure Monitoring

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“…In a nationwide study with a median follow-up of 4.7 years, Banegas et al [9] observed that masked hypertension was more strongly associated with all-cause mortality than sustained hypertension (HR: 2.85 vs. 1.80; P < 0.001, respectively). Previous studies have also shown that masked hypertension was associated with increased left ventricular mass index, increased carotid intima-media thickness, albuminuria, and stroke [35,39]. This well-documented increase in morbidity and mortality risk associated with masked hypertension provides a good rationale for its treatment.…”

Section: Discussionmentioning

confidence: 90%

Long-term effect of masked hypertension management on cognitive functions in geriatric age: geriatric MASked hypertension and cognition follow-up study (G-MASH-cog MONITOR)

Balcı

Eşme

Sümer

et al. 2021

Blood Pressure Monitoring

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Objectives Masked hypertension, defined as nonelevated clinic blood pressure with elevated out of clinic blood pressure, has been associated with increased cardiovascular events, mortality and cognitive impairment. No evidence exists regarding the effect of treating masked hypertension. In this study, we followed-up the patients in the G-MASH-cog study for 1 year and aimed to examine the effect of the management of masked hypertension on cognitive functions. Methods The G-MASH-cog study participants were followed-up for 1 year. In masked hypertensive individuals, lifestyle modification and antihypertensive treatment (perindopril or amlodipine) were initiated for blood pressure control. Measurements of cognitive tests and ambulatory blood pressure monitoring at baseline and at 1-year follow-up were compared. Results A total of 61 patients (30 in masked hypertension group; 31 in normotensive group) were included. Mean age was 72.3 ± 5.1 and 59% of the participants were female. Compared with baseline ambulatory blood pressure measurement results, patients with masked hypertension had significantly lower ambulatory blood pressure measurement results after 1-year follow-up. The quick mild cognitive impairment test (Q-MCI-TR) score increased with antihypertensive treatment (Q-MCI score at baseline = 41(19–66.5), at 1 year = 45.5 (22–70), P = 0.005) in masked hypertensive patients. In the final model of the mixed-effects analysis, when adjusted for covariates, interaction effect of the masked hypertension treatment with time was only significant in influencing the changes in Q-MCI scores over time in patients aged between 65 and 74 years (P = 0.002). Conclusions Treatment of masked hypertension in older adults was associated with improvement in cognitive functions.

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Which is responsible for target organ damage in masked hypertension? Is it an increase in blood pressure or a disruption of the circadian rhythm?

Akbay

Çoner

Akıncı

et al. 2021

Clinical and Experimental Hypertension

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Masked hypertension is associated with end organ damage in geriatric age: Geriatric MASked Hypertension and End organ damage (G-MASH-End organ Study)

Cited by 4 publications

References 22 publications

Aortic arch calcification: a novel parameter for prediction of masked hypertension

Aortic arch calcification: a novel parameter for prediction of masked hypertension

Long-term effect of masked hypertension management on cognitive functions in geriatric age: geriatric MASked hypertension and cognition follow-up study (G-MASH-cog MONITOR)

Which is responsible for target organ damage in masked hypertension? Is it an increase in blood pressure or a disruption of the circadian rhythm?

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