“…In addition, recent studies suggest that changes in temporal and spatial expression of dsx by gene regulatory networks providing positional information may contribute to this diversity [Rideout et al, 2010;Robinett et al, 2010]. A prominent role of dsx in properly implementing the selected sexual developmental program has not only been validated in D. melanogaster [Baker and Wolfner, 1988], but also in other dipterans, M. domestica [Hediger et al, 2004] and C. capitata [Saccone et al, 2008], in the lepidopteran B. mori [Suzuki et al, 2003[Suzuki et al, , 2005 as well as in the coleopterans T. castaneum [Shukla and Palli, 2012a] and horned beetles [Kijimoto et al, 2012]. Hence, dsx is thought to play a widely conserved role in integrating information about sexual identity in the general developmental program [Vincent et al, 2001].…”