2019
DOI: 10.1111/nmo.13623
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Mas‐related G protein‐coupled receptor C11 (Mrgprc11) induces visceral hypersensitivity in the mouse colon: A novel target in gut nociception?

Abstract: Background Visceral hypersensitivity, an important cause of abdominal pain in disorders such as IBD and IBS, presents with a poorly understood pathophysiology and limited treatment options. Several members of the Mas‐related G protein‐coupled receptor family (Mrgprs) have become promising targets in pain research. The potential link between the murine Mrgpr C11 (Mrgprc11) and gut nociception is currently uninvestigated. Therefore, we explored the expression and functional role of Mrgprc11 in the gut nociceptiv… Show more

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Cited by 19 publications
(17 citation statements)
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References 46 publications
(155 reference statements)
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“…In the case of BAM8-22, visceral hypersensitivity to CRD was observed at more noxious distension pressures. This is consistent with very recent findings showing that BAM8-22 evoked elevated pain responses to CRD in healthy mice (40). While intracolonic administration of the individual agonists for TGR5, MrgprA3, and MrgprC11 evoked hypersensitivity to CRD, they did not fundamentally affect spontaneous animal behavior.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…In the case of BAM8-22, visceral hypersensitivity to CRD was observed at more noxious distension pressures. This is consistent with very recent findings showing that BAM8-22 evoked elevated pain responses to CRD in healthy mice (40). While intracolonic administration of the individual agonists for TGR5, MrgprA3, and MrgprC11 evoked hypersensitivity to CRD, they did not fundamentally affect spontaneous animal behavior.…”
Section: Discussionsupporting
confidence: 93%
“…The sensitizing effects of TGR5, MrgprA3, or MrgprC11 agonists on colonic afferents likely occurs via neuronal mechanisms. This is because MRGPRA3 and MRGPRC11 (40) are absent from colonic tissues but are expressed on mouse and human DRG neurons. While TGR5 is expressed on colonic afferents, it is also expressed on colonic epithelial cells and on enteric neurons (41, 42).…”
Section: Discussionmentioning
confidence: 99%
“…In the colon, afferent sensitization occurs via a variety of processes [18], including histamine-dependent mechanisms and histamine-independent mechanisms [19,20]; Evidence have been accumulated that activation of receptors associated with the above two itch pathways on colon-innervating afferents induces visceral hypersensitivity [19,21]. Gastrin-releasing peptide receptor expressing (GRPR)+ neurons have a central role in the spinal transmission of both histaminergic and Fig.…”
Section: Discussionmentioning
confidence: 99%
“…In the colon, afferent sensitization occurs via a variety of processes [16], including histamine-dependent mechanisms and histamine-independent mechanisms [17,18]; Evidence have been accumulated that activation of receptors associated with the above two itch pathways on colon-innervating afferents induces visceral hypersensitivity [17,19]. Gastrin-releasing peptide receptor expressing(GRPR) + neurons have a central role in the spinal transmission of both histaminergic and non-histaminergic itch [20].In our study, GRPR was signi cantly upregulated in IBS-D patients and identi ed as a hub gene by MCODE.…”
Section: Discussionmentioning
confidence: 99%