MarrowDLD: a microfluidic method for label-free retrieval of fragile bone marrow cells
Gloria Porro,
Rita Sarkis,
Clara Obergozo
et al.
Abstract:Functional bone marrow studies have focused primarily on hematopoietic progenitors, leaving limited knowledge about other fragile populations, such as bone marrow adipocytes (BMAds) and megakaryocytes. The isolation of these cells is challenging due to rupture susceptibility and large size. We introduce here a label-free cytometry microsystem, MarrowDLD, based on deterministic lateral displacement. MarrowDLD enables the isolation of fragile cells based on intrinsic size properties while preserving their viabil… Show more
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