Marrow failure and aging: The role of “Inflammaging”

Zhao, Janice; Ghimire, Anima; Liesveld, Jane L.

doi:10.1016/j.beha.2021.101283

Cited by 5 publications

(1 citation statement)

References 88 publications

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“…Chronic inflammation induces the progression of atherosclerosis 41 . Aging is a process that reduces hematopoiesis 42 and increases inflammation 43 . In addition, there is a reduction in the number of circulating hematopoietic stem cells known as CD34-positive cells in elderly individuals as compared to younger individuals 44 .…”

Section: Discussionmentioning

confidence: 99%

Association between atherosclerosis and height loss among older individuals

Shimizu,

Arima,

Yamanashi

et al. 2024

Sci Rep

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Atherosclerosis and height loss are each reportedly associated with cardiovascular disease. However, no studies have found an association between atherosclerosis and height loss. A retrospective study of 2435 individuals aged 60–89 years who underwent annual health check-ups was conducted. Atherosclerosis was defined as carotid intima-media thickness (CIMT) ≥ 1.1 mm. Height loss was defined as being in the highest quintile of height decrease per year, as in our previous studies. Among study participants, 555 were diagnosed as having atherosclerosis. Independent of known cardiovascular risk factors, atherosclerosis was positively associated with height loss. The adjusted odds ratio (OR) was 1.46 (95% confidence interval, 1.15, 1.83). Essentially the same associations were observed for men and women. The adjusted OR (95% CI) was 1.43 (1.01, 2.04) for men and 1.46 (1.07, 1.99) for women. Among older individuals, atherosclerosis is associated with height loss. This result can help clarify the mechanism underlying the association between height loss and cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

Association between atherosclerosis and height loss among older individuals

Shimizu,

Arima,

Yamanashi

et al. 2024

Sci Rep

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Factors associated with clonal hematopoiesis and interaction with marrow environment

Nannya

2022

J Bone Miner Metab

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Deciphering cytopenias in internal medicine: a single-center observational study

Leoni,

Ferraresi,

Motta

et al. 2024

Intern Emerg Med

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Cytopenia is a common finding in patients admitted to internal medicine wards and the clinical workup may be long and time-consuming. In this single-center observational study, we analyzed a series of 151 inpatients who received hematologist referral due to cytopenia observed during hospital admission. Patients were mainly elderly (median 71 years, 15–96) and 87% had at least one comorbidity. Anemia was the most common cytopenia (91%), followed by thrombocytopenia (51%), and neutropenia (22%); 73 (48%) patients had a bicytopenia and 5 (3%) pancytopenia. Cytopenias were mainly severe, 66% of cases required RBC transfusions, and 21% platelet pools. During a median hospital stay of 15 days (1–166), 53 subjects (35%) received a hematologic discharge diagnosis, whilst the two-thirds had secondary cytopenia mainly due to associated comorbidities. Only about 34% of 2,728 diagnostic tests performed (including laboratory, imaging, and histology) clearly informed the discharge diagnosis in this heterogenous setting. Specifically, bone-marrow evaluation indicated in 46 (30%) patients, was diagnostic in 32 (69.6%). Eleven percent of patients died due to progression of the oncohematologic disease (29%), sepsis (24%), and solid tumor progression (24%). In conclusion, cytopenias in the internal medicine setting are mainly severe, more frequently secondary to associated comorbidities (2/3 of patients) and deserve proper workup before second/third-level tests (immune-hematological assays and CT scan or PET and bone-marrow evaluation, respectively).

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Marrow failure and aging: The role of “Inflammaging”

Cited by 5 publications

References 88 publications

Association between atherosclerosis and height loss among older individuals

Association between atherosclerosis and height loss among older individuals

Factors associated with clonal hematopoiesis and interaction with marrow environment

Deciphering cytopenias in internal medicine: a single-center observational study

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