Marrow-Derived Mesenchymal Stem Cells Restore Biochemical Markers of Acute Liver Injury in Experimental Model

Gruttadauria, Salvatore; Grosso, Giuseppe; Pagano, Domenico; Biondi, Antonio; Echeverri, Gabriel J.; Seria, Elisa; Pietrosi, Giada; Liotta, Rosa; Burzotta, Francesco; Gridelli, Bruno

doi:10.1016/j.transproceed.2012.06.087

Cited by 15 publications

(10 citation statements)

References 14 publications

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“…In another study, Gruttadauria et al [86] transplanted BM-MSCs which had not undergone pretreatment with growth factors. As a result stem cells could attenuate ALI and transduce hepatic recovery either incubated or not with hepatogenic mediators [86].…”

Section: Resultsmentioning

confidence: 99%

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Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

Papanikolaou

Katselis

Αποστόλου

et al. 2017

Stem Cells International

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Mesenchymal stem cells (MSCs) are an attractive source for regenerative medicine because they are easily accessible through minimally invasive methods and have the potential to enhance liver regeneration (LG) and improve liver function, following partial hepatectomy (PH) and acute or chronic liver injury. A systematic review of the literature was conducted for articles published up to September 1st, 2016, using the MEDLINE database. The keywords that were used in various combinations were as follows: “Mesenchymal stem cells”, “transplantation”, “stem cells”, “adipose tissue derived stem cells”, “bone marrow-derived stem cells”, “partial hepatectomy”, “acute liver failure”, “chronic liver failure”, “liver fibrosis”, “liver cirrhosis”, “rats”, “mice”, and “liver regeneration”. All introduced keywords were searched for separately in MeSH Database to control relevance and terminological accuracy and validity. A total of 41 articles were identified for potential inclusion and reviewed in detail. After a strict selection process, a total of 28 articles were excluded, leaving 13 articles to form the basis of this systematic review. MSCs transplantation promoted LG and improved liver function. Furthermore, MSCs had the ability to differentiate in hepatocyte-like cells, increase survival, and protect hepatocytes by paracrine mechanisms. MSCs transplantation may provide beneficial effects in the process of LG after PH and acute or chronic liver injury. They may represent a new therapeutic option to treat posthepatectomy acute liver failure.

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Section: Resultsmentioning

confidence: 99%

“…As a result stem cells could attenuate ALI and transduce hepatic recovery either incubated or not with hepatogenic mediators [86]. …”

Section: Resultsmentioning

confidence: 99%

Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

Papanikolaou

Katselis

Αποστόλου

et al. 2017

Stem Cells International

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“…Previously, others have shown that bone marrow-derived mesenchymal stem cells promote hepatic regeneration after CCl 4 treatment in rats (Gruttadauria et al, 2013; Li et al, 2013). Hatch and colleagues recently proposed that the SDF-1alpha-CXCR4 axis is important for oval (LPC) cell activation during liver regeneration.…”

Section: Signaling Pathways and Markers Of Lpcmentioning

confidence: 99%

Role of liver progenitors in acute liver injury

Best¹,

Dollé²,

Manka³

et al. 2013

Front. Physiol.

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Acute liver failure (ALF) results from the acute and rapid loss of hepatocyte function and frequently exhibits a fulminant course, characterized by high mortality in the absence of immediate state-of-the-art intensive care and/or emergency liver transplantation (ELT). The role of hepatocyte-mediated liver regeneration during acute and chronic liver injury has been extensively investigated, and recent studies suggest that hepatocytes are not exclusively responsible for the regeneration of the injured liver during fulminant liver injury. Liver progenitor cells (LPC) (or resident liver stem cells) are quiescent in the healthy liver, but may be activated under conditions where the regenerative capacity of mature hepatocytes is severely impaired. This review aims to provide an overview of the role of the LPC population during ALF, and the role of putative cytokines, growth factors, mitogens, and hormones in the LPC response. We will highlight the potential interaction among cellular compartments during ALF, and discuss the possible prognostic value of the LPC response on ALF outcomes.

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“…Most of the studies used intravenous MSC administration, but others chose the intra-portal route 29,215 aiming at circumventing trapping in the pulmonary circulation 215 . Overall, MSC decreased the severity of histological liver injury 74,75,210,213–215 , improved liver function 75,210–212,215 and finally enhanced survival 29,74,75,210,213–215 . In contrast, Boeykens et al did not find any benficial effects of intraportally administrated MSC in terms of improved liver recovery 218 .…”

Section: Mesenchyaml Stem Cells In Acute Liver Failurementioning

confidence: 90%

Cell-based Therapy for Acute Organ Injury

et al. 2014

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Critically ill patients often suffer from multiple organ failures involving lung, kidney, liver or brain. Genomic, proteomic and metabolomic approaches highlight common injury mechanisms leading to acute organ failure. This underlines the need to focus on therapeutic strategies affecting multiple injury pathways. The use of adult stem cells such as mesenchymal stem or stromal cells (MSC) may represent a promising new therapeutic approach as increasing evidence shows that MSC can exert protective effects following injury through the release of pro-mitotic, anti-apoptotic, anti-inflammatory and immunomodulatory soluble factors. Furthermore, they can mitigate metabolomic and oxidative stress imbalance. In this work, we review the biological capabilities of MSC and the results of clinical trials using MSC as therapy in acute organ injuries. Although preliminary results are encouraging, more studies concerning safety and efficacy of MSC therapy are needed to determine their optimal clinical use.

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Marrow-Derived Mesenchymal Stem Cells Restore Biochemical Markers of Acute Liver Injury in Experimental Model

Cited by 15 publications

References 14 publications

Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

Role of liver progenitors in acute liver injury

Cell-based Therapy for Acute Organ Injury

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