Marriage Is As Protective As Chemotherapy in Cancer Care

Kissane, David W.

doi:10.1200/jco.2013.51.5080

Cited by 28 publications

(24 citation statements)

References 15 publications

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“…Obviously, insurance directly effects patients’ access to healthcare, either via screening for early diseases or persisting to the conclusion of treatments . Although marriage seems to be a more protective factor for males than for females, our results were in alignment with previous studies that married women have more favorable survival . Investments in the healthcare system and cancer treatment largely depend on the economic power of a country or a state, which is closely correlated with medical level and inclusion in universal health coverage .…”

Section: Discussionsupporting

confidence: 85%

“…Recently, more attention has focused on the socioeconomic determinants of breast cancer survival. Aizer et al showed that the survival benefit associated with marriage for breast cancer patients was even greater than for chemotherapy and that married patients were less likely to develop metastatic disease . Insurance has been proven to affect the stage at diagnosis, chemotherapy initiation, adjuvant endocrine therapy adherence, and survival of breast cancer .…”

Section: Introductionmentioning

confidence: 99%

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Association between socioeconomic factors at diagnosis and survival in breast cancer: A population‐based study

Gong

Jiang

et al. 2020

Cancer Medicine

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Background The associations between socioeconomic statuses and survival outcomes of breast cancer remain unclear. No model has included both histological and socioeconomic factors to predict the survival of breast cancer. This study was designed to develop nomograms to predict breast cancer–specific survival (BCSS) and overall survival (OS) with consideration of socioeconomic factors for breast cancer patients. Materials and methods We included a total of 207 749 female patients, diagnosed with malignant breast cancer between 2007 and 2012 from the Surveillance, Epidemiology, and End Results database. BCSS and OS were evaluated with Gray's test and log‐rank tests, respectively. Marital statuses, insurance statuses, residence, median household income, poverty rate, unemployment rate, and education level were included as socioeconomic factors in univariate and multivariate Cox regression analyses. Clinicopathological factors and socioeconomic factors were integrated to construct nomograms. Calibration plots and concordance indexes (C‐indexes) were used to evaluate the accuracy and discrimination of the models. Results Four and three socioeconomic factors were involved in constructing the nomograms for 3‐, 5‐, and 7‐year BCSS and OS, respectively. The C‐indexes of the final nomograms were higher than those of the TNM staging system for predicting BCSS (0.835 vs 0.782; P < .001) and OS (0.773 vs 0.676; P < .001). The performance of the nomograms for predicting OS was significantly lower when excluding socioeconomic factors (P < .001). Conclusion These findings may highlight the importance of developing health‐related policies and the necessity of targeted social support‐based interventions for high‐risk patients.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Association between socioeconomic factors at diagnosis and survival in breast cancer: A population‐based study

Gong

Jiang

et al. 2020

Cancer Medicine

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“…It has been suggested that this may be due to the standard diagnostic nomenclature for depression being not completely applicable to men [145,146] and that diagnosis of depression in men requires the inclusion of additional symptoms [145,[147][148][149][150]. Some of those symptoms include aggression, irritability, and alcohol use, none of which are included in the diagnostic criteria for Major Depressive Disorder in the DSM-5 [4]or ICD-10 [151].…”

Section: Frontal Asymmetry and Gender Differencesmentioning

confidence: 99%

Frontal alpha asymmetry as a pathway to behavioural withdrawal in depression: Research findings and issues

Jesulola

Sharpley

Bitsika

et al. 2015

Behavioural Brain Research

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“…Several other studies have been published since then for cancers in general, and HNC, in particular, which further substantiate these findings (Aizer et al, ; Inverso et al, ; Martinez et al, ; Osazuwa‐Peters, Adjei Boakye, Chen, Tobo, & Varvares, ; Schaefer et al, ; Shi, Zhang, Hu, & Ji, ). These studies provide evidence that being married has a protective effect on cancer survival for many cancers including HNC (de Graeff et al, ; Kissane, ). This protective impact of being married may be due to several mechanisms, including enhanced surveillance leading to earlier presentation for investigation for some subsites, while reducing cancer‐related behaviour (smoking pre‐ or post‐diagnosis) through social and emotional support provided by a spouse (de Graeff et al, ).…”

Section: Introductionmentioning

confidence: 98%

What's Love Got to do with it? Marital status and survival of head and neck cancer

et al. 2019

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Objective To determine whether marital status independently predicts survival in a head and neck cancer (HNC) survivor population. Methods In this retrospective cohort study, we analysed data from 460 adult patients (59.31 ± 11.42) years diagnosed with HNC at an academic tertiary referral centre between 1997 and 2012. Cox proportional hazards model estimated the effect of marital status on survival. Results Our study had 73% men, and 82.2% were Whites. We found an association between marital status and HNC survival. Unmarried HNC patients had a 66% increase in hazard of death compared to married patients (aHR = 1.66, 95% CI = 1.23–2.23). This was after controlling for sociodemographic variables (age, race, sex and health insurance status), social habits (tobacco and alcohol), primary anatomical subsite (oral cavity, oropharyngeal, laryngeal and others), stage at presentation (early vs. late stage) and treatment modality (surgery, surgery with adjuvant therapies, other single modality therapy and palliative care). Conclusions Being married confers survival advantage for HNC survivors. Our finding underscores the need to recognise this aspect of survivorship. Social support should be considered part of standard care for managing HNC. There may also be need to develop other support mechanisms, especially for unmarried HNC survivors.

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Marriage Is As Protective As Chemotherapy in Cancer Care

Cited by 28 publications

References 15 publications

Association between socioeconomic factors at diagnosis and survival in breast cancer: A population‐based study

Association between socioeconomic factors at diagnosis and survival in breast cancer: A population‐based study

Frontal alpha asymmetry as a pathway to behavioural withdrawal in depression: Research findings and issues

What's Love Got to do with it? Marital status and survival of head and neck cancer

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