Marqueurs biologiques de l’inflammation et risque d’accident vasculaire cérébral ischémique après un accident ischémique transitoire

Daoussi, N.; Mahmoud, I.; Aissi, M.; Machraoui, Rafik; Mokni, N.; Younes, S.; Frih-Ayed, Mahbouba

doi:10.1016/j.neurol.2017.01.320

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“…Assessment of us CRP, as a cardiovascular risk factor, had shown an increase in 20 % of the study population. These results are similar to those of the study by Nizar et al, which showed a frequency of 31% [17] . CRP us has been shown to be a prognostic factor in ischemic stroke; indeed, elevation of CRP us would reflect the severity of the ischemic stroke in the acute phase [18] .…”

Section: Discussionsupporting

confidence: 92%

Biochemical and hematological profiles of subjects with cryptogenic ischemic stroke

Djite¹,

NM²,

PM³

et al. 2022

Int. J. Adv. Biochem. Res.

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Cryptogenic ischemic stroke refers to a DVA for which no specific cause has been detected after adequate investigation. It is an emerging concept whose increasing frequency is currently a public health problem. Thus, the objective of this study was to determine the biochemical and hematological profiles of subjects with cryptogenic ischemic stroke. This is a descriptive and analytical study of patients with cryptogenic stroke followed at the neurological clinic of the CHNU of Fann. The study included 40 patients matched to 40 healthy controls according to sex and age ±2 years. All biochemical parameters were measured with the Architect ci4100 (Abbott, Chicago, USA) using enzymatic techniques and hematological parameters were measured with the XN-1000 (Sysmex, France). The study population consisted of 40 subjects with cryptogenic ischemic stroke. The mean age of our patients was 47 ± 11 years and the sex ratio was 1.35. The main cardiovascular risk factors found were hypertension (45%), dyslipidemia (23%) and diabetes (15%). Evaluation of biochemical parameters showed significant differences in HDL-C (p<0.0001) and LDL-C (p<0.0001). Hyperuricemia was the most frequent biochemical abnormality (47%) followed by hypercholesterolemia (20%). Hematological abnormalities were mainly anemia (22%), lymphocytosis (35%) and platelet line abnormalities (15%). The results obtained suggest that the profile of biochemical and hematological parameters is associated with several disturbances including anemia, hyperuricemia, and lymphocytosis, thus showing the high susceptibility of stroke subjects to multiple infections.

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Section: Discussionsupporting

confidence: 92%