Marmesin is a novel angiogenesis inhibitor: Regulatory effect and molecular mechanism on endothelial cell fate and angiogenesis

Kim, Jae Hyun; Kim, Jinkyu; Ahn, Eun‐Kyung; Ko, Hyejin; Cho, Young‐Rak; Lee, Choong Hyun; Kim, Yong Kee; Bae, Gyu‐Un; Oh, Joa Sub; Seo, Dong Wan

doi:10.1016/j.canlet.2015.09.021

Cited by 24 publications

(25 citation statements)

References 44 publications

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“…Marmesin treatment markedly suppressed mitogen-induced expression of cyclin-dependent kinase 4 (Cdk4), but not Cdk2, to levels observed in the untreated controls, resulting in inhibition of pRb phosphorylation in both NSCLC cell lines. Marmesin has previously been reported to inhibit proliferation by downregulation of Cdk4, Cdk2 and cyclin D in VEGF-A-treated HUVECs (14). Although the molecular mechanism of marmesin in regulating cell cyclerelated proteins appears slightly different in cell types, these findings demonstrate the antiproliferative activity of marmesin against various types of cells, independently of p53 expres- sion status.…”

Section: Resultsmentioning

confidence: 67%

“…Previous investigations have demonstrated that B. kazinoki extract and its bioactive components such as flavan derivatives have anti-diabetic, anti-allergic, anti-inflammatory and antitumor properties (7)(8)(9)(10)(11)(12). We recently reported that an ethanolic extract of B. kazinoki and marmesin regulate VEGF-A-induced endothelial cell fates in vitro and angiogenic sprouting ex vivo (13,14). Marmesin, a furanocoumarin component isolated from a variety of plants including Peucedanum japonicum, Dystaenia takeshimana, Feronia limonia and Ferula lutea as well as B. kazinoki, has been reported to exert a variety of pharmacological functions such as anti-inflammatory, antihepatotoxic, anti-angiogenic and antitumor activities (14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

“…We recently reported that an ethanolic extract of B. kazinoki and marmesin regulate VEGF-A-induced endothelial cell fates in vitro and angiogenic sprouting ex vivo (13,14). Marmesin, a furanocoumarin component isolated from a variety of plants including Peucedanum japonicum, Dystaenia takeshimana, Feronia limonia and Ferula lutea as well as B. kazinoki, has been reported to exert a variety of pharmacological functions such as anti-inflammatory, antihepatotoxic, anti-angiogenic and antitumor activities (14)(15)(16)(17)(18). However, the effects and molecular mechanisms of marmesin on NSCLC cell responses have never been elucidated, to date.…”

Section: Introductionmentioning

confidence: 99%

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Marmesin-mediated suppression of VEGF/VEGFR and integrin β1 expression: Its implication in non-small cell lung cancer cell responses and tumor angiogenesis

Kim

Lee

et al. 2016

Oncology Reports

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In the present study, we investigated the effects and molecular mechanism of marmesin, a natural coumarin compound isolated from Broussonetia kazinoki, on non-small cell lung cancer (NSCLC) cell responses and tumor angiogenesis. Marmesin abrogated mitogen-stimulated proliferation and invasion in both p53 wild-type A549 and p53-deficient H1299 NSCLC cells. These antitumor activities of marmesin were mediated by the inactivation of mitogenic signaling pathways and downregulation of cell signaling-related proteins including vascular endothelial growth factor receptor-2 (VEGFR-2), integrin β1, integrin-linked kinase and matrix metalloproteinases-2. Furthermore, marmesin suppressed the expression and secretion of VEGF in both NSCLC cells, leading to inhibition of capillary-like structure formation in human umbilical vein endothelial cells. Collectively, these findings demonstrate the pharmacological roles and molecular targets of marmesin in regulating NSCLC cell responses and tumor angiogenesis.

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Section: Resultsmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Marmesin-mediated suppression of VEGF/VEGFR and integrin β1 expression: Its implication in non-small cell lung cancer cell responses and tumor angiogenesis

Kim

Lee

et al. 2016

Oncology Reports

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“…Quiescent HUVECs (4 × 10 4 cells/mL) were added to Matrigel ® ‐coated plates and treated with conditioned media for 12 hours. Tube formation was observed with an Olympus CKX41 inverted microscope (CAchN 10/0.25php objective) and ToupTek Toupview software (version ×86, 3.5.563, Hangzhou ToupTek Photonics Co.) …”

Section: Methodsmentioning

confidence: 99%

Novel functions for 2‐phenylbenzimidazole‐5‐sulphonic acid: Inhibition of ovarian cancer cell responses and tumour angiogenesis

Kim

Ahn

et al. 2020

J Cellular Molecular Medi

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In this study, we investigated the effects and molecular mechanisms of 2‐phenylbenzimidazole‐5‐sulphonic acid (PBSA), an ultraviolet B protecting agent used in sunscreen lotions and moisturizers, on ovarian cancer cell responses and tumour angiogenesis. PBSA treatment markedly blocked mitogen‐induced invasion through down‐regulation of matrix metalloproteinase (MMP) expression and activity in ovarian cancer SKOV‐3 cells. In addition, PBSA inhibited mitogen‐induced cell proliferation by suppression of cyclin‐dependent kinases (Cdks), but not cyclins, leading to pRb hypophosphorylation and G1 phase cell cycle arrest. These anti‐cancer activities of PBSA in ovarian cancer cell invasion and proliferation were mediated by the inhibition of mitogen‐activated protein kinase kinase 3/6‐p38 mitogen‐activated protein kinase (MKK3/6‐p38MAPK) activity and subsequent down‐regulation of MMP‐2, MMP‐9, Cdk4, Cdk2 and integrin β1, as evidenced by treatment with p38MAPK inhibitor SB203580. Furthermore, PBSA suppressed the expression and secretion of vascular endothelial growth factor in SKOV‐3 cells, leading to inhibition of capillary‐like tubular structures in vitro and angiogenic sprouting ex vivo. Taken together, our results demonstrate the pharmacological effects and molecular targets of PBSA on modulating ovarian cancer cell responses and tumour angiogenesis, and suggest further evaluation and development of PBSA as a promising chemotherapeutic agent for the treatment of ovarian cancer.

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“…Also, the role of marmesin coumarin in angiogenesis regulation was evidenced [47]. High cost of treatment, current used drugs' side effects, emerge of drug resistance and first of all, the risk hazards of cancer [7], make it paramount necessity to turn to natural drug origin remedy.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic, cytotoxic, antioxidant and antitrematodal medicinal efficacy of polar and non-polar phytochemicals of Balanites aegyptiaca Del.

Al-Ashaal¹

2017

APJTD

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Marmesin is a novel angiogenesis inhibitor: Regulatory effect and molecular mechanism on endothelial cell fate and angiogenesis

Cited by 24 publications

References 44 publications

Marmesin-mediated suppression of VEGF/VEGFR and integrin β1 expression: Its implication in non-small cell lung cancer cell responses and tumor angiogenesis

Marmesin-mediated suppression of VEGF/VEGFR and integrin β1 expression: Its implication in non-small cell lung cancer cell responses and tumor angiogenesis

Novel functions for 2‐phenylbenzimidazole‐5‐sulphonic acid: Inhibition of ovarian cancer cell responses and tumour angiogenesis

Antidiabetic, cytotoxic, antioxidant and antitrematodal medicinal efficacy of polar and non-polar phytochemicals of Balanites aegyptiaca Del.

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