In the Bayesian community, an ongoing imperative is to develop efficient algorithms. An appealing approach is to form a hybrid algorithm by combining ideas from competing existing techniques. This paper addresses issues in designing hybrid methods by considering selected case studies: the delayed rejection algorithm, the pinball sampler, the Metropolis adjusted Langevin algorithm, and the population Monte Carlo algorithm. We observe that even if each component of a hybrid algorithm has individual strengths, they may not contribute equally or even positively when they are combined. Moreover, even if the statistical efficiency is improved, from a practical perspective there are technical issues to be considered such as applicability and computational workload. In order to optimize performance of the algorithm in real time, these issues should be taken into account.