Market Withdrawal of Vioxx: Is it Time to Retihink the Use of COX-2 Inhibitors?

2,5-Dimethyl-Celecoxib Inhibits Cell Cycle Progression and Induces Apoptosis in Human Leukemia Cells

“…Moreover, COX-2 inhibitors are able to sensitize tumors to chemotherapy, radiotherapy, or photodynamic therapy (Cao and Prescott, 2002;Sobolewski et al, 2010). Despite these beneficial effects, chronic use of COX-2 specific inhibitors and non-steroidal anti-inflammatory drugs were recently associated with severe side effects, including gastric ulcers or increased risks of stroke or myocardial infarction (Ortiz, 2004;Hudson et al, 2007). Moreover, antitumor properties of these molecules are not necessarily depending on COX-2 inhibition (Schonthal, 2006;Ryan et al, 2008).…”

Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats

“…Such therapies are helpful in controlling the symptoms of acute RA, but their effects on chronic, prolonged RA are unsatisfactory. Moreover, the adverse effects of drug therapy are significant and include gastrointestinal disturbances, infections and cardiovascular risks (Scheiman, 2001;Mangge et al, 2003;Rubbert-Roth and Perniok, 2003;Ortiz, 2004). The inflammatory process of RA is reportedly associated with an increase of the pro-inflammatory cytokines TNF-␣ and IL-1␤ (Dayer, 2003;Fleischmann et al, 2004;Shin et al, 2003).…”

New evidence rekindles the hormone therapy debate

“…37,38 In contrast, the major external validity problem for RCTs of HT is under-representation of relatively young (postmenopausal) women rather than the elderly. Although recent analyses of discrepancies between the RCTs and observational studies have focused much of their attention on disparities in the underlying ages and durations since menopause of study participants, additional WHI limitations may have given rise to the conflicting findings.…”