In this paper, we build on a long research effort aimed at identifying the specific conditions, functional and structural characteristics of urban areas, that produce different levels of residential segregation across cities. We explore segregation levels in Poland's 87 largest cities, cities with more than 50,000 residents, by measuring indices of dissimilarity relating to socioprofessional status. We then proceed by examining core structural determinants of the revealed segregation levels, including city size, and housing market characteristics. The results suggests that the structural characteristics of urban regions are indeed significant predictors of the level of socio-spatial disparities in urban Poland. As expected, larger cities are more segregated than the smaller ones; higher shares of public housing also appear to contribute to more pronounced socioeconomic spatial divisions. Intriguingly, the share of new housing stock alone is not related to strong residential segregation.