2013
DOI: 10.4137/bmi.s12537
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Markers that can Reflect Asthmatic Activity before and after Reduction of Inhaled Corticosteroids: A Pilot Study

Abstract: Evaluation of airway inflammation is important in achieving adequate dosing of inhaled corticosteroids (ICS) for treating bronchial asthma. However, there is no evaluation tool that can be used in clinical settings. We examined biomarkers that can precisely reflect airway inflammation when ICS are decreased in stable asthmatic patients. This was a 12-week, single-arm, open-label clinical study performed at a single university hospital. Twenty-five patients (6 male and 19 female) with stable asthma were include… Show more

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Cited by 25 publications
(13 citation statements)
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References 31 publications
(46 reference statements)
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“…In cross‐sectional studies, patients who were treated with ICS had significantly lower values of NO x and NT in the EBC compared to steroid‐naïve asthmatic individuals . These findings corroborate the expectation that corticosteroid treatment may suppress the inhibition of oxidative stress and the pro‐inflammatory response in the inflamed airways . Exhaled breath condensate H 2 O 2 levels derived from those with current symptoms of asthma are higher than those without symptoms.…”
Section: Discussionsupporting
confidence: 67%
See 1 more Smart Citation
“…In cross‐sectional studies, patients who were treated with ICS had significantly lower values of NO x and NT in the EBC compared to steroid‐naïve asthmatic individuals . These findings corroborate the expectation that corticosteroid treatment may suppress the inhibition of oxidative stress and the pro‐inflammatory response in the inflamed airways . Exhaled breath condensate H 2 O 2 levels derived from those with current symptoms of asthma are higher than those without symptoms.…”
Section: Discussionsupporting
confidence: 67%
“…Most studies that assessed the associations of the EBC oxidative stress markers in inflammatory airways of asthma diseases have relied on a cross‐sectional design. Additional longitudinal studies are needed in order to improve the utility of EBC collection and measurement of biomarkers to (i) predict responsiveness to specific pharmacological therapies such as corticosteroids in patients with asthma (ii) help determine the prognosis of disease, (iii) evaluate stability these markers over time, (iv) if the changes in these biomarkers are related to changes in asthma severity or (v) can predict remission of disease .…”
Section: Discussionmentioning
confidence: 99%
“…But if they show low serum periostin, administration of other agents should be considered because type 2 antagonists would be ineffective for them. 56 This result is compatible with the notion that serum periostin, as a biomarker, reflects hyporesponsiveness to ICS.…”
Section: Periostin As a Biomarker To Predict Hyporesponsiveness To Icssupporting
confidence: 88%
“…Periostin, a protein of the extracellular matrix induced by IL-4 and IL-13 in the lung epithelial cells and in fibroblasts, plays a role in epithelial fibrosis and infiltration of the tissues by the eosinophils [78,79]. Serum periostin has been proposed as a biomarker of allergic asthma: high serum periostin levels are correlated with lung eosinophilia [80] and respiratory function [81] and are predictive of the response to ICSs [82,83], omalizumab [84], and lebrikizumab (anti-IL13 antibody). Furthermore, a faster decline in respiratory function has been seen observed when serum periostin levels are high [85].…”
Section: Periostinmentioning
confidence: 99%