Markers of systemic inflammation in children with hyperuricemia

Wasilewska, Anna; Tenderenda, Edyta; Taranta-Janusz, Katarzyna; Tobolczyk, Jolanta; Stypułkowska, Justyna

doi:10.1111/j.1651-2227.2011.02582.x

Cited by 34 publications

(32 citation statements)

References 20 publications

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“…Excessive production of uric acid may result in impaired endothelial function (Choi et al, 2014). In this study, it was shown that increased levels of uric acid were correlated with the elevation of hs-CRP, which is consistent with a previous study (Wasilewska et al, 2012). The hs-CRP is an essential indicator of atherosclerosis (Kamath et al, 2015) and the findings lead to the proposal that serum uric acid might be a relevant marker for cardiovascular disease.…”

Section: Discussionsupporting

confidence: 93%

Hyperuricemia in Children and Adolescents with Autism Spectrum Disorder Treated with Risperidone: The Risk Factors for Metabolic Adverse Effects

et al. 2017

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Background: Atypical antipsychotics have been found to be associated with hyperuricemia. Risperidone, one of the atypical antipsychotics, might be related to the hyperuricemia among autism spectrum disorder (ASD) patients. The aims of this study were to determine the prevalence of hyperuricemia in ASD patients treated with risperidone and to determine associations between serum uric acid levels and risperidone dosage, treatment duration, and metabolic parameters.Methods: 127 children and adolescents with ASD treated with risperidone and 76 age-matched risperidone-naïve patients with ASD were recruited. The clinical data and laboratory data were analyzed. Hyperuricemia was defined as serum uric acid >5.5 mg/dl.Results: Hyperuricemia was present in 44.70% of risperidone-naïve patients with ASD and 57.50% of ASD patients treated with risperidone. The fasting uric acid levels were significantly higher in the risperidone group than in the risperidone-naïve group (5.70 vs. 5.35 mg/dl, P = 0.01). The increased uric acid concentrations were significantly associated with adolescent patients treated with risperidone. The higher dose of risperidone and/or the longer treatment time were associated with the increased uric acid levels. Uric acid levels significantly rose with body mass index (BMI), waist circumference (WC), triglyceride (TG) levels, triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C), insulin levels, homeostatic model assessment index (HOMA-IR), high-sensitivity CRP (hs-CRP) levels, and leptin levels. Conversely, the levels of HDL-C and adiponectin were negatively correlated with uric acid levels. In multiple regression analysis, there were age, BMI, TG/HDL-C ratio, and adiponectin levels remained significantly associated with uric acid levels.Conclusion: Hyperuricemia may play a role in metabolic adverse effect in children and adolescents with ASDs receiving the high dose and/or the long-term treatment with risperidone.

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Section: Discussionsupporting

confidence: 93%

Hyperuricemia in Children and Adolescents with Autism Spectrum Disorder Treated with Risperidone: The Risk Factors for Metabolic Adverse Effects

et al. 2017

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“…The results must be adjusted for birthweight and BMI, after collecting more samples. Initial conclusion from this preliminary study confirms the observation of Verd and Fraga (1).…”

Section: Is Duration Of Breastfeeding In Infancy Associated With Serusupporting

confidence: 89%

“…Sir, It is with great interest that we read the paper by Wasilewska et al (1). They document the positive associations between hyperuricemia and markers of systemic inflammation (MCP-1 and hs-CRP) in normotensive children and reinforce previous papers on the relationship between uricaemia and systemic inflammation in humans.…”

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confidence: 53%

Markers of low‐grade inflammation, breastfeeding and uric acid concentration

Verd

Fraga

2012

Acta Paediatrica

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“…Very little is also known about the proinflammatory properties of SDMA. Median serum SDMA levels in HU patients was significantly higher compared to the controls, similarly like hs-CRP, wich was also confirmed in our previous study in similar population [30]. The results of this study showed that similarly ADMA and SDMA correlated positively with serum hs-CRP.…”

Section: Discussionsupporting

confidence: 90%

Asymmetric and Symmetric Dimethylarginine in Adolescents with Hyperuricemia

et al. 2013

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The purpose of this work was to investigate if in adolescents with hyperuricemia serum levels of asymmetric and symmetric dimethylarginine (ADMA, SDMA) are increased and if their levels correlate with serum uric acid (UA). Patients and Methods. The study group consisted of 58 hyperuricemic patients aged median 16.15 Q1–Q3 (14–17). The reference group contained 27 healthy individuals with normal serum UA level. ADMA and SDMA were measured by immunoenzymatic ELISA commercial kits and expressed in μmol/L. Serum UA was measured by the colorimetric method. Results. In hyperuricemic patients serum ADMA values did not differ between two estimated groups (P > 0.05); however, SDMA was significantly higher than in reference group (P < 0.01). Serum ADMA and SDMA correlated positively with UA (r = 0.34, P < 0.01) (r = 0.31, P < 0.01) and hs-CRP (r = 0.20, P < 0.05) (r = 0.36, P < 0.01), respectively. Conclusion. We demonstrated increased SDMA but not ADMA levels in adolescents with hyperuricemia and their correlation with serum uric acid levels. However, at the moment it is difficult to answer the question if it is just coexistence of these factors or any mechanism linking uric acid and methylated arginines really exists.

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Markers of systemic inflammation in children with hyperuricemia

Abstract: Serum MCP-1 and hs-CRP are elevated in hyperuricemic patients, but the role of obesity in inflammation markers needs further investigation.

Cited by 34 publications

References 20 publications

Hyperuricemia in Children and Adolescents with Autism Spectrum Disorder Treated with Risperidone: The Risk Factors for Metabolic Adverse Effects

Hyperuricemia in Children and Adolescents with Autism Spectrum Disorder Treated with Risperidone: The Risk Factors for Metabolic Adverse Effects

Markers of low‐grade inflammation, breastfeeding and uric acid concentration

Asymmetric and Symmetric Dimethylarginine in Adolescents with Hyperuricemia

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