Markers of Systemic Inflammation in Experimental Dyslipidemia Induced by P-407: Modulation with Fucoidan from Brown Alga Fucus evanescens

Кузнецова, Т. А.; Ivanushko, L. A.; Persiyanova, E. V.; Ermakova, Svetlana P.; Беседнова, Н. Н.

doi:10.1007/s10517-019-04436-w

Cited by 14 publications

(11 citation statements)

References 11 publications

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“…Fucoidan treatment ameliorated all increases in VLD-cholesterol, total cholesterol, and TG levels caused by P-407. In addition, strong anti-inflammatory effects were found [76]. In both cases, no differences in the effects based on the delivery route were found.…”

Section: Fucoidansmentioning

confidence: 86%

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Hypolipidemic Effects of β-Glucans, Mannans, and Fucoidans: Mechanism of Action and Their Prospects for Clinical Application

et al. 2020

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The search for lipid-lowering drugs is important for clinical medicine. This review summarizes our research findings regarding the hypolipidemic activity of polysaccharides. There are several validated agents altering lipid levels which reduce the risk of atherosclerotic cardiovascular events. Nonetheless, for many people, the risk of such an event remains unacceptably high despite treatment with these agents. This situation has prompted the search for new therapies to reduce the residual cardiovascular risk. The lipid-lowering effect of β-glucans consumed with food was demonstrated in patients with atherosclerosis. The mechanism of the protective effect of β-glucans is poorly studied. The effects of β-glucans are mediated by Toll-like receptors, by dectin-1, and possibly by other receptors. Nevertheless, the mechanism of the protective action of β-glucan in lipemic mice has been studied insufficiently. This review will present up-to-date information regarding experimental hypolipidemic polysaccharide compounds that hold promise for medicine. Phagocyte-specific chitotriosidase in humans contributes to innate immune responses against chitin-containing fungi. This enzyme has been first described in patients with Gaucher disease and serves as an important diagnostic biomarker. It has been reported that, in mice, chitin particles of certain size are recognized by macrophages through Toll-like receptors, dectin-1, and to a lesser extent through mannose receptor.

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Section: Fucoidansmentioning

confidence: 86%

“…Fucoidans are water-soluble complex polysaccharide mainly containing l-fucose and sulfate groups found mostly in brown seaweed and sea cucumbers. This polysaccharide is believed to have several promising therapeutic properties [75,76]. It can be found mostly in marine brown algae and echinoderms [77,78].…”

Section: Fucoidansmentioning

confidence: 99%

Hypolipidemic Effects of β-Glucans, Mannans, and Fucoidans: Mechanism of Action and Their Prospects for Clinical Application

et al. 2020

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“…An inflammatory response is present during the formation of atherosclerotic plaques and high levels of inflammatory cytokines in the serum have been used as an important predictor for AS. Recent studies have shown that fucoidan treatment reduces inflammatory cytokines in RAW264.7 macrophages and mice [25][26][27][28][29]. Low molecular weight fucoidan regulates the production and expression of inflammatory cytokines including IL-6, IL-10, phosphorylated c-Jun N-terminal kinase(p-JNK) and cyclin D1 and inhibits the inflammation associated with AS [14].…”

Section: Fucoidanmentioning

confidence: 99%

Current Research Landscape of Marine-Derived Anti-Atherosclerotic Substances

et al. 2020

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Atherosclerosis is a chronic disease characterized by lipid accumulation and chronic inflammation of the arterial wall, which is the pathological basis for coronary heart disease, cerebrovascular disease and thromboembolic disease. Currently, there is a lack of low-cost therapeutic agents that effectively slow the progression of atherosclerosis. Therefore, the development of new drugs is urgently needed. The research and development of marine-derived drugs have gained increasing interest from researchers across the world. Many marine organisms provide a rich material basis for the development of atherosclerotic drugs. This review focuses on the latest technological advances in the structures and mechanisms of action of marine-derived anti-atherosclerotic substances and the challenges of the application of these substances including marine polysaccharides, proteins and peptides, polyunsaturated fatty acids and small molecule compounds. Here, we describe the theoretical basis of marine biological resources in the treatment of atherosclerosis.

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“…Однако главным объектом совместных исследований долгое время были полисахариды из бурых водорослей Fucus evanescens. Для ряда БАВ, созданных на их основе, были изучены молекулярные механизмы иммуномодулирующего, антибактериального, антикоагулянтного, антитоксического, противовирусного, радиопротективного действия, исследованы взаимосвязи между структурой веществ и их биологическими свойствами [6][7][8].…”

Section: полисахариды из бурых водорослей Fucus Evanescensunclassified

“…Обоснована возможность создания инновационных лекарственных средств на их основе. Получены данные, свидетельствующие о возможности использования фукоидана из Fucus evanescens и его структурных аналогов в качестве эффективных и безопасных адъювантов в составе противовирусных вакцин [6][7][8].…”

Section: полисахариды из бурых водорослей Fucus Evanescensunclassified

Molecular-biological and biomedical investigations in FEB RAS. Some modern results and perspectives of the marine natural products studies

Мищенко¹,

Федореев²,

Крылова³

et al. 2020

Вестник ДВО РАН

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Рассмотрены некоторые результаты молекулярно-биологических и биомедицинских исследований, выполненных в основном в 2019–2020 гг. В исследованиях принимали участие Тихоокеанский институт биоорганической химии им. Г.Б. Елякова ДВО РАН, другие институты ДВО РАН, Научно-исследовательский институт эпидемиологии и микробиологии им. Г.П. Сомова, а также научные организации из Республики Корея, Вьетнама, Германии и других стран. Some examples of the molecular studies on natural products and their medico-biological properties were discussed in this short review. All these studies were carried out in 2019–2020. G.B. Elyakov Pacific Institute of Bioorganic Chemistry of the Far-Eastern Branch of the Russian Academy of Science, other scientific organizations of FEB RAS, G.P. Somov Research Institute of Epidemiology and Microbiology, as well as collaborators from foreign countries such as Republic of Korea, Socialistic Republic of Vietnam, Germany took also part in the investigation.

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Markers of Systemic Inflammation in Experimental Dyslipidemia Induced by P-407: Modulation with Fucoidan from Brown Alga Fucus evanescens

Cited by 14 publications

References 11 publications

Hypolipidemic Effects of β-Glucans, Mannans, and Fucoidans: Mechanism of Action and Their Prospects for Clinical Application

Hypolipidemic Effects of β-Glucans, Mannans, and Fucoidans: Mechanism of Action and Their Prospects for Clinical Application

Current Research Landscape of Marine-Derived Anti-Atherosclerotic Substances

Molecular-biological and biomedical investigations in FEB RAS. Some modern results and perspectives of the marine natural products studies

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