Markers of Recurrence and Long-Term Morbidity in Craniopharyngioma: A Systematic Analysis of 171 Patients

Gautier, A; Godbout, Ariane; Grosheny, C.; Tejedor, Isabelle; Coudert, Mathieu; Courtillot, Carine; Jublanc, Christel; Kerdanet, M. de; Poirier, Jean-Yves; Riffaud, Laurent; Sainte‐Rose, Christian; Effenterre, R. Van; Brassier, G.; Bonnet, Fabrice; Touraine, Philippe; Thibaud, E

doi:10.1210/jc.2011-2817

Cited by 107 publications

(99 citation statements)

References 36 publications

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“…It has been clearly shown that children rarely have the papillary type tumor. Gautier reported that 61 children had the adamantinomatous type tumors compared with only 3 other children with the papillary type ones [2]. In our study, none of the children had the papillary type tumor.…”

Section: Discussioncontrasting

confidence: 51%

“…An important finding of our study was that children had more frequent post-operative complication of diabetes insipidus than adults. Gautier et al found that patients with early onset disease (age <10 years) had a significantly higher morbidity rate [2]. Lower awareness of increased intracranial pressure (IICP) might facilitate the brain tumor progression.…”

Section: Discussionmentioning

confidence: 99%

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Comparison Study of Clinical Presentation and Surgical Outcome between Children and Adults with Craniopharyngioma: A 22-Year Single-Center Experience in Southern Taiwan

Chu¹,

Su²,

Lieu³

et al. 2017

Journal of Neurological Disorders

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Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Comparison Study of Clinical Presentation and Surgical Outcome between Children and Adults with Craniopharyngioma: A 22-Year Single-Center Experience in Southern Taiwan

Chu¹,

Su²,

Lieu³

et al. 2017

Journal of Neurological Disorders

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“…HI of CP has been reported as a major risk factor to impairment of long-term survival (7,8,14) and quality of life (8,21,22,23,24,25,26,27,28,29,30) in CP patients. The question of whether DOH before diagnosisspecifically whether prolonged interval between the first appearance of symptoms and the time of diagnosiscontributes to adverse sequelae and impaired survival had not been answered before this study.…”

Section: Discussionmentioning

confidence: 99%

History before diagnosis in childhood craniopharyngioma: associations with initial presentation and long-term prognosis

Hoffmann

Boekhoff

Gebhardt

et al. 2015

European Journal of Endocrinology

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Objective: Childhood craniopharyngiomas (CP) are often diagnosed after a long duration of history (DOH). Tumor size, hypothalamic involvement (HI), and obesity are associated with reduced overall survival (OS) and functional capacity (FC). The effect of DOH and specific symptoms in history on presentation at initial diagnosis and long-term prognosis are unknown. Design: Retrospective analysis of patients' records and prospective longitudinal follow-up. Methods: Histories of 411 CP patients recruited in HIT Endo, KRANIOPHARYNGEOM 2000 were retrospectively evaluated for DOH, symptoms, and characteristics. The effect of specific manifestations and DOH on clinical presentation and tumor characteristics at time of initial CP diagnosis and long-term outcome were analyzed. Main outcome measures were 10-year OS and progression-free survival (PFS), FC, and BMI during longitudinal follow-up. Results: Median DOH was 6 months (range: 0.1-108 months) and correlated with age at diagnosis. Tumor size, HI, degree of resection, and BMI at diagnosis were not related to DOH. In multivariate analysis adjusted for age at diagnosis, only hydrocephalus was found to have a relevant influence on DOH. Visual and neurological deficits were associated with larger initial tumor size and impaired 10-year OS. Weight gain and growth failure were observed with longest DOH. PFS and FC were not related to any specific symptom. Endocrine deficits at diagnosis were associated with long DOH. Conclusions: CP is frequently diagnosed after long DOH, especially in older children. However, DOH was not associated with tumor size, HI, survival, or FC. Visual and neurological deficits necessitate rapid diagnostic workup.

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“…This trend has also been seen in other studies but is limited in our analysis due to small sample size and a variety of characteristics that reflect treatment decisions. 14 Residual symptoms are also expected to have an impact in QOL. Both long-term visual deficits and endocrine deficits were associated with decreased QOL.…”

Section: Predictors Of Increased or Decreased Postoperative Qolmentioning

confidence: 99%

Long-term quality of life after endonasal endoscopic resection of adult craniopharyngiomas

Patel

Raza

McCoul³

et al. 2015

JNS

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T he management of craniopharyngiomas is fraught with challenges that not only hinder achievement of optimal oncological outcomes but potentially have adverse effects on the quality of life (QOL). At time of presentation, and certainly after treatment, craniopharyngiomas can be associated with visual field defects, endocrinopathies, hypothalamic syndromes, increased cardiovascular risk, and neurocognitive sequelae. 7,9,33,37,46 Although considered benign tumors, their location can impact critical structures such as the optic nerves and chiasm, hypoabbreviatioNs ASBQ = Anterior Skull Base Quality of Life; BMI = body mass index; GTR = gross-total resection; QOL = quality of life; obJect Craniopharyngiomas are benign parasellar tumors for which surgical removal, although potentially curative, often leads to morbidity with resulting decreases in quality of life (QOL). The endonasal endoscopic approach is a minimal-access technique for removing these tumors and may reduce postoperative morbidity. The QOL following this method for resection of craniopharyngiomas has not been documented. methods The authors reviewed a database of consecutive endonasal endoscopic surgeries done at Weill Cornell Medical College. Adult patients with histologically proven craniopharyngiomas were included who had completed either only postoperative (> 9 months) or both pre- and postoperative QOL forms, the Anterior Skull Base Quality of Life (ASBQ) questionnaire, and the 22-Item Sinonasal Outcome Test (SNOT-22). Rates of gross-total resection (GTR), complications, and visual and endocrine function were collected. Retrospective independence (Wen score) was also assigned. A contemporaneous group of patients undergoing endonasal endoscopic pituitary macroadenoma resection was used as a control. results This study included 33 procedures performed in 31 patients. The average postoperative ASBQ score was 3.35 and the SNOT-22 score was 19.6. Better QOL was associated with GTR and postoperative radiation. Worse QOL was associated with persistent visual defects, hypopituitarism, tumor recurrence, increase in body mass index, and worsening Wen score. In a subset of 10 patients, both pre- and postoperative (> 9 months) QOL scores were obtained. Both ASBQ and SNOT-22 scores showed stability and a trend toward improvement, from 2.93 ± 0.51 to 2.96 ± 0.47 (ASBQ) and . Compared with 62 patients undergoing endoscopic pituitary macroadenoma resection, patients with craniopharyngiomas had worse postoperative QOL on the ASBQ (3.35 vs 3.80; p = 0.023) and p = 0.12). coNclusioNs This report of validated site-specific QOL following endoscopic surgery for craniopharyngiomas shows an overall maintenance of postoperative compared with preoperative QOL. Better QOL could be seen in patients with GTR and radiation therapy, and worse QOL was found in patients with visual or endocrine deficits. Nevertheless, patients with craniopharyngiomas still had worse QOL than those undergoing similar surgery for pituitary macroadenomas, confirming the worse prognosis of craniop...

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Markers of Recurrence and Long-Term Morbidity in Craniopharyngioma: A Systematic Analysis of 171 Patients

Cited by 107 publications

References 36 publications

Comparison Study of Clinical Presentation and Surgical Outcome between Children and Adults with Craniopharyngioma: A 22-Year Single-Center Experience in Southern Taiwan

Comparison Study of Clinical Presentation and Surgical Outcome between Children and Adults with Craniopharyngioma: A 22-Year Single-Center Experience in Southern Taiwan

History before diagnosis in childhood craniopharyngioma: associations with initial presentation and long-term prognosis

Long-term quality of life after endonasal endoscopic resection of adult craniopharyngiomas

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