Markers of neutrophil chemotaxis for identification of blood stream infections in children with acute lymphoblastic leukemia undergoing induction treatment

Weischendorff, Sarah; Pietri, Silvia; Rathe, Mathias; Frandsen, Thomas Leth; Hasle, Henrik; Nielsen, Claus Henrik; Moser, Claus; Müller, Klaus

doi:10.1111/ejh.13962

Cited by 4 publications

(2 citation statements)

References 50 publications

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“…After bone marrow transplantation, there is a decrease in CXCL1 levels in the blood even below the levels found in healthy individuals [91]. In pediatric patients with ALL, an elevated level of both CXCL1 and CXCL8 is associated with an increased likelihood of bloodstream infections (BSI) [93]. This is related to the fact that CXCR2 ligands are involved in mobilizing neutrophils from the bone marrow, particularly during infections [94].…”

Section: Acute Lymphocytic Leukemiamentioning

confidence: 99%

The Clinical Significance and Involvement in Molecular Cancer Processes of Chemokine CXCL1 in Selected Tumors

Korbecki,

Bosiacki,

Szatkowska

et al. 2024

IJMS

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Chemokines play a key role in cancer processes, with CXCL1 being a well-studied example. Due to the lack of a complete summary of CXCL1’s role in cancer in the literature, in this study, we examine the significance of CXCL1 in various cancers such as bladder, glioblastoma, hemangioendothelioma, leukemias, Kaposi’s sarcoma, lung, osteosarcoma, renal, and skin cancers (malignant melanoma, basal cell carcinoma, and squamous cell carcinoma), along with thyroid cancer. We focus on understanding how CXCL1 is involved in the cancer processes of these specific types of tumors. We look at how CXCL1 affects cancer cells, including their proliferation, migration, EMT, and metastasis. We also explore how CXCL1 influences other cells connected to tumors, like promoting angiogenesis, recruiting neutrophils, and affecting immune cell functions. Additionally, we discuss the clinical aspects by exploring how CXCL1 levels relate to cancer staging, lymph node metastasis, patient outcomes, chemoresistance, and radioresistance.

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Section: Acute Lymphocytic Leukemiamentioning

confidence: 99%

The Clinical Significance and Involvement in Molecular Cancer Processes of Chemokine CXCL1 in Selected Tumors

Korbecki,

Bosiacki,

Szatkowska

et al. 2024

IJMS

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“…Fecal samples were collected on treatment day 1 (range − 2 − 5), 8 (5)(6)(7)(8)(9)(10)(11), 15 (13)(14)(15)(16)(17)(18), 22 (20)(21)(22)(23)(24)(25) and 29 (27)(28)(29)(30)(31)(32)(33)(34), for a total of 185 samples (median 4, range 1-5, per patient). The number of samples available for each time-point is reported in Supplementary Table 1.…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota changes are associated with prolonged neutropenia after induction treatment of childhood acute lymphoblastic leukemia

Sørum,

Boulund,

De Pietri

et al. 2024

Preprint

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Prolonged neutrophil recovery during acute lymphoblastic leukemia (ALL) treatment increases infection risk and delays chemotherapy. Emerging evidence implicates the gut microbiota in neutrophil reconstitution after chemotherapy. We explored the interplay between the gut microbiota and neutrophil dynamics, including neutrophil chemoattractants, in 51 children with newly-diagnosed ALL. Daily absolute neutrophil count (ANC), weekly plasma chemokines (CXCL1 and CXCL8), granulocyte colony-stimulating factor (G-CSF), and fecal samplings were monitored until day 29 during ALL induction treatment. Fecal sequencing by 16S rRNA revealed an overall significant reduction in bacterial diversity and Enterococcus overgrowth throughout the induction treatment. Prolonged neutropenia (ANC < 0.5x109 cells/L at day 36) and elevated chemokines levels were associated with decreased abundance of genera from the Ruminococcaceae and Lachnospiraceae families, decreased Veillonella genus, and Enterococcus overgrowth from diagnosis and throughout induction treatment. G-CSF was upregulated in response to neutropenia but unrelated to microbiota changes. Overall, this study reveals that diminished abundance of specific intestinal commensals and Enterococcus overgrowth are associated with delayed neutrophil reconstitution and increased chemokine signaling. These findings enhance our understanding of the mechanisms behind the huge variability in neutrophil reconstitution post-chemotherapy, emphasizing the need for gut microbiota-sparing strategies to minimize the impact of gut dysbiosis on immune recovery.

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Intestinal mucositis, systemic inflammation and bloodstream infections following high‐dose methotrexate treatment in childhood acute lymphoblastic leukaemia: Comparison between the NOPHO ALL 2008 protocol and the ALLTogether1 protocol

Weischendorff,

de Pietri,

Rathe

et al. 2024

Intl Journal of Cancer

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Severe intestinal mucositis (IM) increases the risk of bloodstream infections (BSI) and inflammatory toxicity during acute lymphoblastic leukaemia (ALL) induction treatment. However, the implications of IM in subsequent ALL therapy phases after achieving remission remain unknown. This study investigated the relationship between IM (measured by plasma citrulline and the chemokine CCL20) and the development of BSI and systemic inflammation (reflected by C‐reactive protein, CRP) in children with ALL during high‐dose methotrexate (HDMTX) treatment, an important part of ALL consolidation therapy. The study compared patients treated according to the NOPHO ALL 2008 protocol (n = 52) and the ALLTogether1 protocol (n = 42), both with identical HDMTX procedures but different scheduling. One week post‐HDMTX, citrulline dropped to median levels of 14.5 and 16.9 μM for patients treated according to the NOPHO ALL 2008 and ALLTogether1 protocols, respectively (p = 0.11). In a protocol and neutrophil count‐adjusted analysis, hypocitrullinaemia (<10 μmol/L) was associated with increased odds of BSI within 3 weeks from HDMTX (OR = 26.2, p = 0.0074). Patients treated according to the NOPHO ALL 2008 protocol exhibited increased mucosal‐ and systemic inflammation post‐HDMTX compared to patients treated according to ALLTogether1, with increased CCL20 (14.6 vs. 3.7 pg/mL, p < 0.0001) and CRP levels (10.0 vs. 1.0 mg/L, p < 0.0001). Both citrulline and CCL20 correlated with CRP for these patients (rs = −0.44, p = 0.0016 and rs = 0.35, p = 0.016, respectively). These results suggest that hypocitrullinaemia following HDMTX increases the risk of BSI, confirming previous observations from more intensive treatments. Moreover, these data indicate that the patients' vulnerability to mucositis and inflammatory toxicity after chemotherapy varies with treatment protocol.

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Markers of neutrophil chemotaxis for identification of blood stream infections in children with acute lymphoblastic leukemia undergoing induction treatment

Cited by 4 publications

References 50 publications

The Clinical Significance and Involvement in Molecular Cancer Processes of Chemokine CXCL1 in Selected Tumors

The Clinical Significance and Involvement in Molecular Cancer Processes of Chemokine CXCL1 in Selected Tumors

Gut microbiota changes are associated with prolonged neutropenia after induction treatment of childhood acute lymphoblastic leukemia

Intestinal mucositis, systemic inflammation and bloodstream infections following high‐dose methotrexate treatment in childhood acute lymphoblastic leukaemia: Comparison between the NOPHO ALL 2008 protocol and the ALLTogether1 protocol

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